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Mark J. Ranek

Mark J. Ranek

Primary Department Affiliation: Cardiology-Medicine; Secondary: Pharmacology and Molecular Sciences
Degree: Ph.D., University of South Dakota
Rank: Assistant Professor
Phone: 410-955-4813
Fax: 410-367-2225
Email: mranek1@jhmi.edu
School of Medicine Address: Room 850, Ross Building, 720 Rutland Avenue, Baltimore, MD  21205 


Targeting proteotoxicities.

Dr. Ranek’s current research interests in the Institute of CardioScience at Johns Hopkins University aim to develop new and more effective treatments for various forms of cardiovascular disease. In particular, Dr. Ranek has focused on the role of proteostasis (protein homeostasis) during cardiac disease pathogenesis towards heart failure. In response to a cardiac stress there is an increased demand placed on the heart, which often manifests as protein misfolding, mutation, oxidation, and/or damage. These proteins must be promptly removed to avoid protein aggregation and a further deterioration of cardiac function. Dr. Ranek’s research has uncovered pathways that are perturbed following a cardiac stress, causing impaired or insufficient proteostasis. Recently his lab has focused on the underlying mechanisms of cardiac amyloidosis and testing novel therapeutic strategies to improve cardiac proteostasis, thereby function. His research as garnered support from the Amyloidosis Foundation, Pfizer, and the American Heart Association.

  


Representative Publications:  

  • Ranek, M.J., Oeing, C., Sanchez-Hodge, R., Kokkonen-Simon, K.M., Dillard, D., Aslam, M.I., Rainer, P.P., Mishra, S., Dunkerly-Eyring, B., Holewinski, R.J., Virus, C., Zhang, H., Mannion, M.M., Agrawal, V., Hahn, V., Lee, D.I., Sasaki, M., Van Eyk, J.E., Willis, M.S., Page, R.C., Schisler, J.C. and Kass, D.A. CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury. Nat Commun. 2020;11:5237. Pub Med Reference 

  • Ranek, M.J., Kokkonen-Simon, K.M., Chen, A., Dunkerly-Eyring, B.L., Vera, M.P., Oeing, C.U., Patel, C.H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R.J., Van Eyk, J.E., Powell, J.D., Lee, D.I., Kass, D.A. PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress. Nature 2019;566:264-269. Pub Med Reference 

  • Ranek, M.J., Zheng, H., Huang, W., Kumarapeli, A.R., Li, J., Liu, J., Wang, X. Genetically induced moderate inhibition of 20s proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload. Journal of Molecular and Cellular Cardiology 2015;85:273-281. Pub Med Reference  

  • Ranek, M.J., Terpstra, E.J., Li, J., Kass, D.A., Wang, X. Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins. Circulation 2013;128:365-376. Pub Med Reference  

  • Oeing, C.U., Mishra, S., Dunkerly-Eyring, B.L., Ranek, M.J. Targeting PKG to treat cardiac proteotoxicity. Front Physiol. 2020;11:858. Pub Med Reference  

  • Mishra, S., Dunkerly-Eyring, B.L., Keceli, G., Ranek, M.J. Phosphorylation modifications regulating cardiac protein quality control mechanisms. Front Physiol. 2020;11:593585. Pub Med Reference 

 


Other graduate program in which Dr. Ranek participates:

  • None