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Netz Arroyo

Arroyo

Department Affiliation: Pharmacology and Molecular Sciences
Degree: Ph.D., University of Texas
Rank: Assistant Professor
Telephone Number: 443-287-4798
E-mail address: netzarroyo@jhmi.edu
School of Medicine Address: 316 Hunterian Building, 725 N. Wolfe St., Baltimore, MD 21205
Lab Website: 
https://netzarroyo.jh.edu/

 

 

Exploiting Biology-Inspired Electrochemical Sensing to Study the Fate of Molecules in the Body

The ability to monitor arbitrary molecules in situ in the body as we undergo normal daily routines could empower us to make educated decisions regarding our diet, fitness, medical treatments and overall health status. Our laboratory pursues this vision by developing biology-inspired electrochemical sensors that support real-time, continuous measurements of a wide range of physiologically-important molecules in vivo. Our research blends chemistry with engineering, biophysics and pharmacology to, for example, study factors involved in the recognition of small-molecule targets by nucleic acid- or peptide-based receptors, develop metabolism-responsive drug delivery approaches, and produce diagnostic platforms for personalized health care. We pursue these goals in an environment that nurtures creativity, inclusivity of ideas, and innovation.

 

Representative Publications:

  • Parolo, C., Greenwood, A.S., Ogden, N.E., Kang, D., Hawes, C., Ortega, G., Arroyo-Currás, N.,  Plaxco, K.W. E-DNA scaffold sensors and the reagentless, single-step, measurement of HIV-diagnostic antibodies in human serum.  Nature Microsyst. Nanoeng. DOI: 10.1038/s41378-019-0119-5, 2020. Nature Reference

  • Shaver, A., Curtis, S., Arroyo-Currás, N. Alkanethiol Monolayer End Groups Affect the Long-term Operational Stability and Signaling of Electrochemical, Aptamer-based Sensors in Biological Fluids. ACS Appl. Mater. Interfaces, DOI: 10.1021/acsami.9b22385, Epub, Mar 4;12(9):11214-11223, 2020. Pub Med Reference

  • Arroyo-Currás, N., Dauphin-Ducharme, P., Scida, K., Chavez, J.L. From the Beaker to the Body: Translational Challenges for Electrochemical, Aptamer-Based Sensors.  Anal. Methods, 2020, DOI: 10.1039/D0AY00026D. Anal. Methods Reference

  • Pellitero, M.A., Shaver, A., Arroyo-Currás, N. Approaches for the Electrochemical Interrogation of DNA-Based Sensors: A Critical Review. J. Electrochem. Soc., 2019. DOI: 10.1149/2.0292003JES. J. Electrochem. Soc. Reference
  • Eden, A., Scida, K., Arroyo-Currás, N., Eijkel, J.C.T., Meinhart, C.D., Pennathur, S. Discharging Behavior of Confined Bipolar Electrodes: Coupled Electrokinetic and Electrochemical Dynamics. Electrochim. Acta, 2019, DOI: 10.1016/j.electacta.2019.135275. Electrochim Acta Reference

  • Dauphin-Ducharme, P., Yang, K., Arroyo-Curras, N., Ploense, K.L., Zhang, Y., Gerson, J., Kurnik, M., Kippin, T.E., Stojanovic, M.N., Plaxco, K.W. Electrochemical Aptamer-based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-controlled Drug Delivery. ACA. Sens., Oct 25;4(10):2832-2837, 2019. Pub Med Reference
  • Curtis, S.D., Ploense, K.L., Kurnik, M., Ortega, G., Parolo, C., Kippin, T.E., Plaxco, K.W., Arroyo-Currás, N. Open Source Software for the Real-Time Control, Processing, and Visualization of High-Volume Electrochemical Data. Anal. Chem.,Oct 1;91(19):12321-12328, 2019. Pub Med Reference 
  • Vieira, P.A., Shin, C., Arroyo-Curras, N., Ortega, G., Li, W., Keller, A.A., Plaxco, K.W., Kippin, T.E. Ultra-high-precision, in-vivo pharmacokinetic measurements highlight the need for and a route towards more highly personalized medicine. Front. Mol. Biosci.Aug 16;6:69, 2019. Pub Med Reference
  • Idili, A., Arroyo-Curras, N., Ploense, K.L., Csordas, A.T., Kuwahara, M., Kippin, T.E., Plaxco, K.W. Seconds-Resolved Pharmacokinetic Measurements of the Chemotherapeutic Irinotecan In Situ in the Living Body. Chem. Sci., Jul 22;10(35):8164-8170, 2019. Pub Med Reference
  • Arroyo-Curras, N., MacKenzie, S., Satik, Y., Meinhart, C.D., Eijkel, J.C.T., Pennathur, S., Scida, K., Eden, A. Fluorescence-Based Observation of Transient Electrochemical and Electrokinetic Effects at Nanoconfined Bipolar Electrodes. ACS Appl. Mater. Interfaces, Apr 10;11(14):13777-13786, 2019. Pub Med Reference
  • Eden, A., Scida, K., Arroyo-Curras, N., Eijkel, J.C.T., Meinhart, C.D., Pennathur, S. Modeling Faradaic Reactions and Electrokinetic Phenomena at a Nanochannel-Confined Bipolar Electrode. J. Phys. Chem. C, 123(9):5353-5364. J. Phys. Chem. Reference
  • Dauphin-Ducharme, P., Arroyo-Currás, N., Plaxco, K.W. High-precision electrochemical measurements of the guanine-, mismatch- and length-dependence of electron transfer from electrode-bound DNA are consistent with a contact-mediated mechanism. J. Am. Chem. Soc., May 15;141(19):8000, 2019. Pub Med Reference 
 

Other graduate programs in which Dr. Arroyo participates:

BCMB Program

Chemistry-Biology Interface

Chemical and Biomolecular Engineering