Clinical Trials

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Clinical Trials can offer benefits to patients, as well as the chance to impact future esophageal cancer treatment. If you would like more information about Esophageal Cancer Clinical Trials offered at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, please contact 410-933-5420.

Current trial listing:

Metastatic – 1st Line

J20131 – Efficacy and Safety of Lenvatinib plus Pembrolizumab plus Chemotherapy in Participants with Advanced/Metastatic Gastroesophageal Adenocarcinoma Compared with Standard of Care Therapy

J2169 – Efficacy and Safety of Pembrolizumab plus Lenvatinib plus Chemotherapy in Patients with Metastatic Esophageal Carcinoma Compared with Standard of Care

Metastatic – 2nd line and beyond

J1884 – REACTION (Radiation Enhanced Assessment of Combination Therapies in Immuno-Oncology) – Nivolumab or Nivolumab/Relatimab after Targeted Systematic Radiation in Participants with Advanced Esophagogastric Cancer

J19135 – Phase 2 Study of Paclitaxel, Pembrolizumab, and Olaparib in Previously Treated Advanced Gastric Adenocarcinoma

J2154 – A Phase 1 Safety Study of SEA-TGT (SGN-TGT) in Participants with Advanced Malignancies

J21111 – Phase I/II Study of Abemaciclib plus Ramucirumab in Metastatic Esophageal/Gastroesophageal Junction Carcinomas


J2084 – A Phase 1b/2 Multicenter, Open-label, Dose-escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antituor Activity of Trastuzumab Deruxtecan (T-DXd) Monotherapy and Combinations in Adult Participants with HER2-Overexpressing Gastric Cancer (DESTINY-Gastric03)

J20120 – A Phase I/II, First-In-Human, Multi-Part, OpenLabel, Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF1001 in Patients With Locally Advanced or Metastatic Solid Tumors, and Expansion in Selected Indications (DF1001-001)

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