Pediatric Hematology

hematology doctor using a microscopeDirector of Hematology James Casella has a special research interest in Sickle Cell Disease and related neurologic complications.

The Division of Pediatric Hematology at Johns Hopkins Children’s Center cares for patients with diseases of the blood or blood-forming organs using the latest technologies and scientific discoveries, bolstered by a history of clinical excellence at Johns Hopkins.

Our Comprehensive Sickle Cell Center specializes in the treatment of central nervous system complications of sickle cell disease for children with sickle cell disease and other related hemoglobinopathies. Continuing our rich tradition of research at Johns Hopkins, we also created the Basic and Translational Research Program in sickle cell disease to continue improving the lives of our patients and families by performing innovative basic research and clinical trials. 

Our Research

  • Role of HMG-I/Y in Leukemia and Lymphoma
    American Cancer Society, funding
  • Pediatric Hydroxyurea Phase III Clinical Trial
    National Institutes of Health, funding
  • Prevention of the Complications of Hemophilia through Hemophilia Treatment
    University of Pennsylvania, funding

  • Mechanisms Controlling Cellular Hemoglobin Content
    National Heart, Lung, and Blood Institute, funding
  • Enhancement of Tumor Cell Killing by Glucocorticoids
    American Cancer Society, funding

Featured Stories

Case Conference: A Toddler with Anuria

For two days this 3-year-old female had a poor appetite, a low grade fever, poor urinary output and abdominal pain with, in her mother’s words, “pink” stools, which prompted a visit to the pediatrician’s office and then to the ED at the local hospital, where the girl was admitted for IV rehydration and pain control.

Contact Us

New Patients: Request an Appointment  

Schedule an Appointment with MyChart

Existing patients can sign up for or log in to MyChart.


Returning Patients and Rescheduling

On-call physician for emergencies after 5 p.m. 

Emergency consultative services (physician-to-physician)

Locations and Directions

Johns Hopkins Children's Center
200 N. Wolfe St
The David M. Rubenstein Child Health Building
Baltimore, MD 21287
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