A small molecule with larger than expected effects on hepatitis B virus
Date:
01/14/2026
Topics:
Citation:
Balagopal A, Cox AL. A small molecule with larger-than-expected effects on hepatitis B virus. Cell Host Microbe. 2026 Jan 14;34(1):15-17. doi: 10.1016/j.chom.2025.12.013. PMID: 41539296.
Abstract
Chronic hepatitis B virus (HBV) affects ∼250 million people worldwide. Functional cure is difficult to achieve with existing medications. In this issue, Fernandes et al. developed a double-humanized chronic HBV murine model to test the capsid assembly modulator GLP-26. GLP-26 reduced blood HBV DNA and surface antigen and induced immunomodulation.