HIV Superinfection in Kidney Transplant Recipients With HIV Who Received Organs From Donors With HIV
Date:
08/14/2025
Citation:
Rozek GM, Yang P, Eby Y, Benner SE, Martens C, Habtehyimer F, Chahoud M, Brown D, Desai NM, Florman S, Rana MM, Pereira MR, Hand J, Mehta SA, Schaenman J, Santos CAQ, Aslam S, Elias N, Odim J, Morsheimer M, Segev DL, Durand CM, Tobian AAR, Redd AD. HIV Superinfection in Kidney Transplant Recipients With HIV Who Received Organs From Donors With HIV. J Infect Dis. 2025 Aug 14;232(2):359-363. doi: 10.1093/infdis/jiaf284. PMID: 40439124; PMCID: PMC12349943.
Abstract
Transplantation of kidneys from donors with HIV to recipients with HIV (HIV D+/R+) has been shown to be safe and effective, but there is a unique risk of donor-derived HIV superinfection (HIV-SI) in these recipients. Recipients from a multicenter observational HIV D+/R+ study were examined for HIV-SI by site-directed next-generation sequencing (Illumina). Eighteen recipients of HIV D+/R+ kidney transplants had baseline and follow-up samples that successfully amplified. One recipient was confirmed to have experienced donor-derived HIV-SI at week 26 but did not experience any clinically significant changes. HIV-SI in recipients of HIV D+/R+ transplants is rare, and the clinical ramifications appear negligible.