Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients
Date:
09/26/2024
Citation:
Johnston TS, Hage C, Abedon AT, Panda S, Alejo JL, Eby Y, Segev DL, Tobian AAR, Cox AL, Werbel WA, Karaba AH. Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients. Clin Infect Dis. 2024 Sep 26;79(3):652-655. doi: 10.1093/cid/ciae279. PMID: 38953683; PMCID: PMC11426267.
Abstract
Durability of variant neutralization in solid organ transplant recipients following Omicron-containing boosters is unknown. We report wane in XBB.1.5 neutralization by 3 months following a first bivalent booster, improved by a second booster; hybrid immunity improved peak, and duration of neutralization. Boosting at 3 to 6 months appears necessary to maintain neutralization.