Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation
Date:
08/04/2023
Topics:
Citation:
Queen J, Shaikh F, Sears CL. Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation. Nat Cancer. 2023 Aug;4(8):1083-1094. doi: 10.1038/s43018-023-00602-2. Epub 2023 Jul 31. PMID: 37525016.
Abstract
The intersection of the microbiota and cancer and the mechanisms that define these interactions are a fascinating, rapidly evolving area of cancer biology and therapeutics. Here we present recent insights into the mechanisms by which specific bacteria or their communities contribute to carcinogenesis and discuss the bidirectional interplay between microbiota and host gene or epigenome signaling. We conclude with comments on manipulation of the microbiota for the therapeutic benefit of patients with cancer.