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Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients. Transplantation

Date:

05/01/2022

Citation:

Mitchell J, Chiang TP, Alejo JL, Chang A, Abedon AT, Avery RK, Tobian AAR, Massie AB, Levan ML, Warren DS, Garonzik-Wang JM, Segev DL, Werbel WA. Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients. Transplantation. 2022 May 1;106(5):e269-e270. doi: 10.1097/TP.0000000000004090. Epub 2022 Mar 3. PMID: 35250006; PMCID: PMC9038243.

Abstract

HLTRs without a previously confirmed coronavirus disease 2019 infection (N = 212) were recruited as previously described.1 Immunosuppression regimens were self-reported, and participants were stratified into 4 groups based on reported total daily dose of MMF: zero MMF, low dose (<1000 mg/d), moderate dose (1000–2000 mg/d), and high dose (≥2000 mg/d). Patients receiving mycophenolic acid were excluded. Antispike antibody testing was performed at 1, 3, and 6 mo after dose 2 using commercially available assays, as previously described.1,3

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https://pubmed.ncbi.nlm.nih.gov/35250006/