To the Editor: We appreciate this powerful patient perspective regarding the ongoing struggles and trade-offs inherent to being an immunosuppressed patient during the coronavirus disease 2019 (COVID-19) pandemic. Living during this pandemic has been challenging, particularly for immunocompromised persons who have not generated antibody response to vaccination and thus remain frustrated and frightened about their continued high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.