CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes from Multiple Prominent SARS-CoV-2 Circulating Variants
Date:
03/30/2021
Topics:
Citation:
Redd AD, Nardin A, Kared H, Bloch EM, Pekosz A, Laeyendecker O, Abel B, Fehlings M, Quinn TC, Tobian AAR. CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants. Open Forum Infect Dis. 2021 Mar 30;8(7):ofab143. doi: 10.1093/ofid/ofab143. PMID: 34322559; PMCID: PMC8083629.
Abstract
This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.