Purpose of Review: This review summarizes both the recent and relevant studies about the treatment of non-Aspergillus hyaline molds.

Recent Findings: Given the rarity of these infections, there have been no large randomized clinical trials regarding the most effective antifungal therapy.

Summary: Although there are more data for the treatment of Fusarium and Scedosporium, there are limited data with case reports that address the other rare hyalohyphomycetes. As we develop improved diagnostic techniques and larger fungal registries, we may be able to determine efficacious treatment modalities. We hope that future research will focus on implementing clinical trials with the new antifungals and ongoing development of novel fungal agents.