Aims: (1) To accelerate equitable cancer control by developing, testing, and refining participatory implementation strategies to decentralize vaccines to prevent cancer in community settings; (2) To enhance the scientific productivity of C3-RISE by providing overarching operational and scientific oversight; (3) To support innovative research and the development of scholars trained to accelerate the uptake and sustainment of evidence-based cancer control interventions in Nigeria. These aims will be accomplished by a nurturing hub of two cores (Administrative, Capacity Building) alongside two research studies (Study 1 focused on HPV vaccination, Study 2 on HBV vaccination).