The long-term goal of the Johns Hopkins Center for Innovative Diagnostics for Infectious Diseases (JH-CIDID) is to accelerate infectious disease diagnostic point-of-care (POC) technology innovation and access in order to impact global public health. Sexually transmitted infections (STIs) and other emerging and re-emerging infectious diseases continue to threaten human health. Syndrome-based empiric algorithmic treatment protocols are widely used since diagnostic test results are often not available as actionable data during a clinical encounter. Since the clinical presentations of many infectious diseases overlap, these protocols often miss asymptomatic infection and/or result in antibiotic overtreatment, which contributes to emerging antimicrobial resistance. There is thus an unmet need for POC and at home infectious disease diagnostics. Timely and actionable diagnostic data will increase the number of patients who are diagnosed and appropriately treated at POC in both the US and in resource-limited settings.