The overarching goal of the JHU TRAC is to catalyze and support innovative, multidisciplinary research and to mentor and train New Investigators (NI) and Early Stage Investigators (ESI) to sustain efforts to end the TB epidemic. The Specific Aims of the JHU TRAC will be to: 1. Enhance the integration, productivity and impact of JHU TB research. The JHU TRAC will serve a convening and coordinating role in bringing together TB Investigators from across JHU to generate interdisciplinary collaborations. The TRAC Administrative Core (AC) will sponsor seminars, symposia, workshops, training programs, and an annual TB scientific meeting to disseminate new information and promote dialogue and interaction between basic, clinical, epidemiologic, and modeling researchers. 2. Provide mentoring, support, and pilot funding for the next generation of TB researchers, and to increase the pipeline of talented NI/ESI from groups Underrepresented in Health-Related Research. The Developmental Core (DC) will recruit NI and ESI, with an emphasis on UHRR groups and those new to TB research, provide mentoring and collaboration opportunities, and access to services to help launch independent careers in TB research. 3. Support TB researchers with direct services from a Clinical Core and three Scientific Cores. Clinical Core (CC); Microbiology, Immunology, Animal Modeling and Imaging (MIAMI) Core; Pharmacology and Pharmacometrics Core (PPC); Bioinformatics, Modeling, and Biostatistics Core (BMBC) 4. Contribute to the END TB goals through global engagement, training, outreach, and collaboration with partners in high burden countries. Working with partners and collaborators at clinical sites in Baltimore and multiple countries, the JHU TRAC will support the development of high-quality research sites, design and implementation of programmatically relevant research studies, and engagement with community and government to produce evidence-based policies to help end the TB epidemic.