The mission of the Clinical Guidelines Program is to develop and disseminate practical, evidence-based clinical guidelines that promote quality medical care for people in New York State (NYS) who are living with or are at risk of acquiring HIV, HCV, STIs, or developing substance use dependence. The program aims to inform primary care providers who do not specialize in these topic areas but who are providing care to people affected by them within NYS. This is accomplished through a guideline development methodology which incorporates current research and evidence as well as the breadth of experience of committee members who specialize in HIV, HCV, STIs, and substance use and who know the realities of providing clinical care throughout NYS and in a broad array of clinical settings. The program is committed to publishing guidelines that are used in the real world by busy care providers, who find them to be useful and readily accessible tools with immediate application in daily practice.