The objectives of this study are to:

 

1. Determine the clinical implications of dynamic changes in the QFT response in 12 months following close contact with a TB patient.

2. Examine if dynamic changes in the QFT response are associated with activation of phenotypically and functionally distinct subsets of T cells.

3. Examine if the dynamic changes in the QFT response are associated with altered macrophage anti-mycobacterial effector responses.