The long-term objective of the Hopkins HIV and Heart, Lung, Blood and Sleep Disorders Training Program (H3TP) is to train and develop a cadre of outstanding investigators who will advance knowledge and improve outcomes for people living with HIV infection (PLWH) and comorbid heart, lung, blood and sleep (HLBS) disorders. This goal is directly relevant to the NHLBI mission and to the Office of AIDS Research high priority research issues to address comorbidities in the setting of aging with HIV. In this proposal, we leverage the outstanding community of HIV and HLBS research at Johns Hopkins including existing clinical and translational infrastructure to support training and research, highly productive program faculty, vibrant interdepartmental and interdivisional multidisciplinary collaborations, excellent institutional commitment to high level training of postdoctoral and early stage investigators.