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Johnston Lab

Principal Investigator: Peter Johnston, MDChao-Wei Hwang, MD
 

Development and optimization of stem cell and regenerative therapies for heart failure and myocardial infarction.

 

Active Projects

  • CardiAMP Heart Failure Trial
  • Implantable Bioreactor for Prevention of Adverse Remodeling after Myocardial Infarction

Publications

1.  Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Steenbergen C, Gerstenblith G, Lange R, Marbán E.  Engraftment, differentiation and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy.  Circulation 2009; 120(12):1075-83.  PMID: 19738142

2.  Makkar R, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet 2012; 379(9819):895-904.  PMID: 22336189

3.  Hare JM, Fishman JE, Gerstenblith G, Velazquez DLD, Zambrano JP, Suncion VY, McNiece IK, Tracy M, Ghersin E, Johnston PV, Brinker JA, Breton E, Davis-Sproul J, Schulman I, Byrnes J, Mendizabal AM, Lowery MH, Rouy D, Altman P, Wong Po Foo C, Ruiz P, Amador A, da Silva J, Heldman AW. Randomized Comparison of Allogeneic vs. Autologous Bone Marrow Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients with Ischemic Cardiomyopathy. JAMA 2012; 308(22):2369-79.  PMID: 23117550

4.  Malliaras K, Makkar RR, Smith, RR, Cheng K, Wu, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E.  Intracoronary cardiosphere-derived cells after myocardial infarction: evidence for therapeutic regeneration in the final 1-year results of the CADUCEUS trial.  J Am Coll Cardiol 2014;63(2):110-22.  PMID: 24036024

5.  Suncion VY, Ghersin E, Zambrano JP, Karantalis V, Mandel N, Nelson KH,  Fishman JE, Gerstenblith G, DiFede DL, Breton E, Sitammagari K,  Schulman IH, Taldone SN, Johnston PV, Brinker JA, Altman P,  Mushtaq M, Trachtenberg B, Mendizabal AM, Da Silva J, McNiece IK, Lardo AC, George RT, Hare JM, Heldman AW. Does Transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally? An analysis from the POSEIDON trial.  Circ Res 2014;114(8):1292-301.  PMID: 24449819

6.  Fu Y, Azene N, Ehtiati T, Flammang A, Gilson WD, Gabrielson K, Weiss CR, Bulte JWM, Johnston PV, Kraitchman DL.  X-ray fusion with magnetic resonance imaging guidance of intrapericardial delivery of microencapsulated human mesenchymal stem cells in non-immunosuppressed swine.  Radiology 2014;272(2):427-37.  PMID: 24749713

7.  Johnston PV and Gerstenblith, G.  Stem Cells for Cardiac Surgical Disease.  In: Johns Hopkins Cardiothoracic Surgery, 2ed.  Yuh, Vircella, Yang, and Doty (eds). McGraw-Hill, New York. 2014.

8.  Hwang CW, Johnston PV, Gerstenblith G, Weiss RG, Tomaselli GF, Bogdan VE, Panigrahi A, Leszczynska A, Xia Z. Stem cell impregnated nanofiber stent sleeve for on-stent production and intravascular delivery of paracrine factors. Biomaterials. 2015 June; 52: 318-26.  PMID: 25818438

Johnston-Hwang Lab Collaborators