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Ciccarone Articles

Ciccarone Center Research

Year

2014

Landmark Articles

Headed in the right direction but at risk for miscalculation: a critical appraisal of the 2013 ACC/AHA risk assessment guideline.
By: Amin NP, Martin SS, Blaha MJ, Nasir K, Blumenthal RS, Michos ED.
The newly released 2013 ACC/AHA Guideline for Assessing Cardiovascular Risk was a major advance over prior guidelines, but the new risk equations do not appear to lead to significantly better discrimination than older models. Since the same risk factors are incorporated, using the new risk estimators may lead to inaccurate assessment of atherosclerotic cardiovascular risk in certain groups of patients. There also is likely an overestimation of risk when applied to modern populations. Future guidelines could provide clearer direction on which individuals would benefit from additional testing for more personalized preventive therapies.
Read on Pubmed
HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: The Lipoprotein Investigators Collaborative.
By: Martin SS, Khokhar AA, May HT, Kulkarni KR, Blaha MJ, Joshi PH, Toth PP, Muhlestein JB, Anderson JL, Knight S, Li Y, Spertus JA, Jones SR; on behalf of the Lipoprotein Investigators Collaborative (LIC).
In secondary prevention, increased risk for long-term hard clinical events is associated with low HDL3-C, but not HDL2-C or HDL-C, highlighting the potential value of subclassifying HDL-C.
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Coronary computed tomography as a cost-effective test strategy for coronary artery disease assessment — a systematic review.
By: Zeb I, Abbas N, Nasir K, Budoff MJ.
CCTA may represent a cost-effective strategy and may be associated with less downstream testing for diagnosis of stable chest pain patients in low- to intermediate-risk patients; for low-risk acute chest pain patients; however, use of CCTA is associated with expedited patient management, less cost and safe exclusion of acute coronary syndrome.
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2013 American cholesterol treatment guideline: what was done well and what could be done better.
By: Martin SS, Abd TT, Jones SR, Michos ED, Blumenthal RS, Blaha MJ.
This article critically appraises the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol. The guideline succeeds in prioritizing statin therapy, expanding focus to atherosclerotic cardiovascular disease including stroke, and in emphasizing absolute cardiovascular risk to determine statin eligibility.
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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
By: Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, et al.
This integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, long-QT syndrome, and sudden cardiac death.
Read on Pubmed
Letter by Jones et al regarding article, “Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation.”
By: Jones SR, Martin SS, Brinton EA.
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Associations of common carotid intima-media thickness with coronary heart disease risk factors and events vary with distance from the carotid bulb.
By: Polak JF, Post WS, Carr JJ, Szklo M, O’Leary DH.
Common carotid artery intima-media thickness (IMT) measurements made below the carotid bulb are smaller but have more consistent associations with CHD risk factors and outcomes compared with IMT measured near the bulb.
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Associations of Pentraxin 3 with cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis.
By: Jenny NS, Blumenthal RS, Kronmal RA, Rotter JI, Siscovick DS, Psaty BM.
In a study of apparently healthy adults, Pentraxin 3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independent of C-reactive protein (CRP) and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP and may provide additional insight into the development and progression of atherosclerosis.
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CPAP versus oxygen in obstructive sleep apnea.
By: Gottlieb DJ, Punjabi NM, Mehra R, Patel SR, Quan SF, Babineau DC, Tracy RP, Rueschman M, Blumenthal RS, Lewis EF, Bhatt DL, Redline S.
In patients with cardiovascular disease or multiple CVD risk factors, the treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP), but not nocturnal supplemental oxygen, resulted in a significant reduction in blood pressure.
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Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the atherosclerosis risk in communities study.
By: Lutsey PL, Alonso A, Selvin E, Pankow JS, Michos ED, Agarwal SK, Loehr LR, Eckfeldt JH, Coresh J.
High levels of serum FGF-23 were associated with increased risk of coronary heart disease, heart failure, and cardiovascular mortality in this large, biracial, population-based cohort.
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