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Ciccarone Articles

Ciccarone Center Research



Landmark Articles

Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the Multi-Ethnic Study of Atherosclerosis: A secondary analysis of a prospective, population-based cohort.
By: Tota-Maharaj R, Blaha MJ, Blankstein R, Silverman M, Eng J, Shaw LJ, Blumenthal RS, Budoff MJ, Nasir K.
The potent predictive value of coronary artery calcium burden applies to middle-aged as well as older adults.
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Association between lipoprotein associated phospholipase A2 mass and subclinical coronary and carotid atherosclerosis in retired national football league players.
By: Pokharel Y, Nambi V, Martin SS, Hoogeveen RC, Nasir K, Khera A, Wong ND, Jones PH, Boone J, Roberts AJ, Ballantyne CM, Virani SS.

Retired National Football League (NFL) players were reported to have high prevalence of cardiovascular risk factors. Lipoprotein Associated Phospholipase A2 (LpPLA2) has shown to be associated with cardiovascular disease in the general population, but it is unknown whether such an association exists in retired NFL players. Our objective was to assess whether LpPLA2 mass was associated with coronary artery calcium (CAC) and carotid artery plaque (CAP) in retired NFL players. LpPLA2 mass was not associated with coronary or carotid subclinical atherosclerosis in retired NFL players.

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Role of troponin in patients with chronic kidney disease and suspected acute coronary syndromes: a systematic review.
By: Stacy SR, Suarez-Cuervo C, Berger Z, Wilson LM, Yeh HC, Bass EB, Michos ED.
In chronic kidney disease patients suspected of having acute coronary syndromes, troponin levels can aid in identifying patients with a poor prognosis, but the diagnostic utility is limited by varying estimates of sensitivity and specificity.
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Prognostic value of cardiac troponins in chronic kidney disease patients without a suspected acute coronary syndrome: a systematic review.
By: Michos ED, Wilson LM, Yeh HC, Berger Z, Suarez-Cuervo C, Stacy SR, Bass EB.
In chronic kidney disease patients without suspected acute coronary syndromes, troponin elevations were associated with worse prognosis.
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Novel biomarkers and risk factors.
By: Cheng HG, Martin SS, Jones SR.
A community-engaged cardiovascular health disparities research training curriculum: Implementation and preliminary outcomes.
By: Golden SH, Purnell T, Halbert J, Matens R, Miller ER, Levine D, Nguyen TH, Gudzune KA, Crews DC, Mahlangu-Ngcobo M, Cooper LA.
This manuscript summarizes the key elements, implementation, and preliminary outcomes of the CVD Disparities Fellowship and Summer Internship Programs at the Johns Hopkins University Schools of Medicine, Nursing, and Bloomberg School of Public Health.
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Role of non-contrast coronary CT for detection of coronary heart disease and cardiovascular disease risk stratification.
By: Waheed S, Nasir K.
A clinician’s guide to the updated ABCs of cardiovascular disease prevention.
By: Kohli P, Whelton SP, Hsu S, Yancy CW, Stone NJ, Chrispin J, Gilotra NA, Houston B, Ashen MD, Martin SS, Joshi PH, McEvoy JW, Gluckman TJ, Michos ED, Blaha MJ, Blumenthal RS.

To facilitate the guideline-based implementation of treatment recommendations in the ambulatory setting and to encourage participation in the multiple preventive health efforts that exist, we have organized several recent guideline updates into a simple ABCDEF approach. We would remind clinicians that evidence-based medicine is meant to inform recommendations but that synthesis of patient-specific data and use of appropriate clinical judgment in each individual situation is ultimately preferred.

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Improving lipid control following myocardial infarction.
By: Ankam J, Feldman DI, Blaha MJ, Martin SS.

Following a myocardial infarction, lipid-lowering therapy is an established intervention to reduce the risk of recurrent cardiovascular events. Prior studies show a need to improve clinical practice in this area. Here, we review the latest research and perspectives on improving postmyocardial infarction lipid control. Optimizing lipid control could further enhance clinical outcomes after myocardial infarction.

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Difference by sex but not by race/ethnicity in the visceral adipose tissue-depressive symptoms association: The Multi-Ethnic Study of Atherosclerosis.
By: Remigio-Baker RA, Allison MA, Schreiner P, Szklo M, Crum RM, Leoutsakos J, Franco M, Carnethon MR, Nettleton J, Mujahid M, Diez Roux AV, Jensky N, Golden SH.
Sex, but not race/ethnicity, was found to modify the relationship between elevated depressive symptoms and visceral fat mass. Among men, a significant positive association was found between depressive symptoms and visceral adiposity, but no significant relationship was found among women.
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