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Ciccarone Articles

Ciccarone Center Research

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Diet & Weight

Landmark Articles

Focused update on the 2013-2014 cardiovascular disease prevention guidelines.
By: Abd TT, Misra S, Ojeifo O, Martin SS, Blumenthal RS, Foody J, Wong ND.
Determinants of intrathoracic adipose tissue volume and associations with cardiovascular disease risk factors in Amish.
By: Liu X, Post WS, McLenithan J, Terrin M, Magder L, Zeb I, Budoff M, Mitchell BD.
These data do not provide support for a significant role for intrathoracic fat in the development of CAC.
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A systematic review of internet-based worksite wellness approaches for cardiovascular disease risk management: outcomes, challenges and opportunities.
By: Aneni EC, Roberson LL, Maziak W, Agatston AS, Feldman T, Rouseff M, Tran TH, Blumenthal RS, Blaha MJ, Blankstein R, Al-Mallah MH, Budoff MJ, Nasir K.
Internet-based programs hold promise for improving the cardiovascular wellness among employees. However, much work is required to fully understand its utility and long-term impact, especially in special/at-risk populations.
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Beyond BMI: the "metabolically healthy obese" phenotype and its association with clinical/subclinical cardiovascular disease and all-cause mortality: a systematic review.
By: Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, Tran T, Blaha MJ, Santos RD, Sposito A, Al-Mallah MH, Blankstein R, Budoff MJ, Nasir K.

This review analyzed the literature that has examined the burden of CVD and all-cause mortality in the metabolically healthy obese population.

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Statin use is not associated with presence of and severity of nonalcoholic fatty liver disease.
By: Oni ET, Sinha P, Karim A, Martin SS, Blaha MJ, Agatston AS, Blumenthal RS, Meneghelo RS, Conceiçao RD, Santos RD, Nasir K.
These results favor statin use in subjects with nonalcoholic fatty liver disease, since its use is not associated with the presence of the disease or increased fibrosis.
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Cardiac complications of obesity.
By: Ashen MD, Blumenthal RS.
Association of depressive symptoms and anti-depressants with body mass index and waist circumference in elderly men and women: The ARIC Carotid MRI Study.
By: Golden SH, Hsu H, Astor BC, Malhotra S, Wand GS, Wasserman BA.

Depressive symptoms are associated with obesity, a precursor to type 2 diabetes and cardiovascular disease, and might in part explain the association of depressive symptoms with adverse metabolic outcomes. We determined the cross-sectional association between depressive symptoms and body mass index (BMI) and waist circumference (WC) in 1,314 elderly men and women age 60 to 83 years in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.

Vegetarian diets in cardiovascular prevention.
By: Ashen MD.

There is growing evidence that consumption of a vegetarian diet as well as specific components of a vegetarian diet lower the incidence of cardiovascular disease (CVD) and death. Vegetarian diets lower the probability of developing CVD, are effective in altering serum lipids, are beneficial in reducing blood pressure, improve glycemic control and insulin sensitivity, reduce weight, and lower mortality. Vascular effects of a vegetarian diet include a thinner carotid IMT and lower brachial artery resistance. Health care providers should be aware of the types of vegetarian diets and their risks and benefits in order to guide patients' dietary habits with the ultimate goal of reducing their CVD risk. While a patient does not have to become a complete vegetarian to reduce their CVD risk, they can make simple changes in their diet that are effective in risk reduction.

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Relation of hepatic steatosis to atherogenic dyslipidemia.
By: Makadia SS, Blaha M, Keenan T, Ndumele C, Jones S, DeFilippis A, Martin S, Kohli P, Conceicao R, Carvalho J, Nasir K, Blumenthal R, Santos RD.
Hepatic steatosis may play a direct metabolic role in conferring increased cardiovascular risk.
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Omega-3 fatty acid blood levels: clinical significance and controversy.
By: Superko HR, Superko SM, Nasir K, Agatston A, Garrett BC.
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