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J. Bill McEvoy, MB BCh, MHS

Ciccarone Center Research

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J. Bill McEvoy, MB BCh, MHS

J. Bill McEvoy, MB BCh, MHS
McEvoy, J. Bill, MB BCH, MHS

J. Bill McEvoy, MB BCH, MHS, is an Assistant Professor of Medicine.

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Landmark Articles

The relationship of cigarette smoking with inflammation and subclinical vascular disease: The Multi-Ethnic Study of Atherosclerosis.

By: McEvoy J, Nasir K, DeFilippis A, Lima J, Bluemke D, Hundley WG, Barr RG, Budoff M, Szklo M, Navas-Acien A, Polak J, Blumenthal R, Post W, Blaha M.

We sought to assess the impact of smoking status, cumulative pack-years, and time since cessation (the latter in former smokers only) on 3 important domains of cardiovascular disease: inflammation, vascular dynamics and function, and subclinical atherosclerosis. These findings expand our understanding of the harmful effects of smoking and help explain the cardiovascular benefits of smoking cessation.

The prognostic value of exercise capacity in patients with coronary artery disease: The FIT Project.

By: Hung RK, Al-Mallah MH, McEvoy JW, Whelton SP, Blumenthal RS, Nasir K, Schairer JR, Brawner C, Alam M, Keteyian SJ, Blaha MJ.
Exercise capacity was a strong predictor of morbidity and mortality in patients with coronary artery disease. Patients with similar exercise capacities had equivalent mortality risk, irrespective of baseline revascularization status.

A clinician’s guide to the updated ABCs of cardiovascular disease prevention.

By: Kohli P, Whelton SP, Hsu S, Yancy CW, Stone NJ, Chrispin J, Gilotra NA, Houston B, Ashen MD, Martin SS, Joshi PH, McEvoy JW, Gluckman TJ, Michos ED, Blaha MJ, Blumenthal RS.

To facilitate the guideline-based implementation of treatment recommendations in the ambulatory setting and to encourage participation in the multiple preventive health efforts that exist, we have organized several recent guideline updates into a simple ABCDEF approach. We would remind clinicians that evidence-based medicine is meant to inform recommendations but that synthesis of patient-specific data and use of appropriate clinical judgment in each individual situation is ultimately preferred.

Coronary artery calcium testing: exploring the need for a randomized trial.

Cigarette smoking worsens systemic inflammation in persons with metabolic syndrome.

By: Jamal O, Aneni EC, Shaharyar S, Ali SS, Parris D, McEvoy JW, Veledar E, Blaha MJ, Blumenthal RS, Agatston AS, Coceicao RD, Feldman T, Carvalho JA, Santos RD, Nasir K.

Emerging data suggests that the combination of smoking and metabolic syndrome (MetS) markedly increases cardiovascular disease risk well beyond that of either condition. In this study we assess if this interaction can be explained by an additive increase in the risk of systemic inflammation by MetS and cigarette smoking. The study demonstrates an additive effect of cigarette smoking on the risk of systemic inflammation in MetS thus highlighting the need for determining smoking status among those with MetS and aggressively targeting smoking cessation in this population.

The turing test and a call to action to improve electronic health record documentation.

By: McEvoy JW.

Clinical informatics represents arguably the most significant advance in medicine since the deciphering of the human genome. In particular, as the “front end” of the clinical informatics revolution, the electronic health record has immense potential to transform modern healthcare. Demonstrated benefits of the electronic health record include decision support, adverse event tracking, and quality control.1 An additional strength of the electronic health record is an inherent capacity to augment research, including embedded, randomized, controlled clinical trials.

ABI and stroke: action at a distance and a call to action.

Risk and the physics of clinical prediction.

By: McEvoy JW, Diamond GA, Detrano RC, Kaul S, Blaha MJ, Blumenthal RS, Jones SR.
This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.

Critical review of high-sensitivity C-reactive protein and coronary artery calcium for the guidance of statin allocation: head-to-head comparison of the JUPITER and St. Francis Heart Trials.

By: Kim J, McEvoy JW, Nasir K, Budoff MJ, Arad Y, Blumenthal RS, Blaha MJ.
This analysis looks at the strengths and limitations of two large trials of statin therapy based on persons with an elevated hsCRP, CAC score, or both.

All-cause mortality in asymptomatic persons with extensive Agatston scores above 1000.

By: Patel J, Blaha MJ, McEvoy JW, Qadir S, Tota-Maharaj R, Shaw LJ, Rumberger JA, Callister TQ, Berman DS, Min JK, Raggi P, Agatston AA, Blumenthal RS, Budoff MJ, Nasir K.
Increasing calcified plaque in coronary arteries continues to predict a graded decrease in survival among patients with extensive Agatston score > 1000 with no apparent upper threshold.