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Ciccarone Center Research
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- Meet the Authors
Published in: Journal of the American College of CardiologyRead on Pubmed
Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial.
This study showed that, in aggregate, an injection of mesenchymal stem cells as a therapy for patients with ischemic cardiomyopathy favorably affected their functional capacity, quality of life, and ventricular remodeling.Published in: Journal of the American Medical AssociationRead on Pubmed
Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) Study.
Low serum magnesium and high serum phosphorus and calcium were independently associated with greater risk of incident HF in this population-based cohort.Read on Pubmed
Metabolomic analysis of pressure-overloaded and infarcted mouse hearts.
These findings reveal extensive metabolic remodeling common to both hypertrophic and failing hearts that are indicative of extracellular matrix remodeling, insulin resistance and perturbations in amino acid, and lipid and nucleotide metabolism.Read on Pubmed
Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the atherosclerosis risk in communities study.
High levels of serum FGF-23 were associated with increased risk of coronary heart disease, heart failure, and cardiovascular mortality in this large, biracial, population-based cohort.
Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem...
Intramyocardial injection of autologous mesenchymal stem cells into akinetic yet nonrevascularized segments produces comprehensive regional functional restitution, which in turn drives improvement in global LV function.
Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally? An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial.
Scar-size reduction and ventricular functional responses preferentially occurred at the sites of transendocardial stem cell injection, compared to nontransendocardial stem cell injection sites.
Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis).
Elevated resting heart rate was associated with increased risk for incident HF in asymptomatic participants in the MESA trial; higher heart rate was related to development of regional and global LV dysfunction independent of subclinical atherosclerosis and coronary heart disease.
Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).
Intracoronary administration of autologous cardiosphere-derived cells did not raise significant safety concerns.