Adamo Cardiac Immunology Lab
The Adamo Cardiac Immunology Lab seeks a deeper understanding of the relationship between the immune system and cardiac function, with the goal of developing novel therapeutic options for patients with heart disease.
Fabiana Pani, M.D.
Fabiana Pani is a physician-scientist with a passion for immunology and discovery. Born and raised in Cagliari (Sardinia, Italy), Fabiana obtained her MD and post graduate training in endocrinology at the Universities of Pisa and Cagliari. During her fellowship, Fabiana developed an interest in autoimmune diseases and endocrinopathies and published several clinical papers. In 2017 Fabiana moved to Johns-Hopkins University to add a basic-science dimension to her work. In Maryland Fabiana completed a first post-doctoral fellowship under the mentorship of Prof. Patrizio Caturegli where she studied autoimmune thyroiditis. In September 2020 she joined the Adamo Lab to expand her post-doctoral training to B cell biology and apply her knowledge of autoimmune disease to the emerging field of cardiac immunology.
Sylvie Rousseau studied Human Biology at Stanford University and worked in international development and global health for several years. She is passionate about improving health outcomes for populations around the world and has special experience in data systems and project reporting as well as communications and workforce training. Sylvie's public health experience includes programs in HIV/AIDS with OVC, human resources for health, and maternal and child health. She has worked with government agencies and nonprofits in Haiti, the Philippines, Uganda, and the United States. With the Adamo Lab since May 2021, Sylvie supports the research activities of her colleagues.
- B cells modulate the expression of MHC-II on cardiac CCR2 macrophages. Rocha-Resende C, Pani F, Adamo L. J Mol Cell Cardiol. 2021 May 8;157:98-103. doi: 10.1016/j.yjmcc.2021.05.003. Epub ahead of print. PMID: 33971183.
- Developmental changes in myocardial B cells mirror changes in B cells associated with different organs.
Rocha-Resende C, Yang W, Li W, Kreisel D, Adamo L, Mann DL.JCI Insight. 2020 Aug 20;5(16):139377. doi: 10.1172/jci.insight.139377.PMID: 32663200
The Emerging Role of B Lymphocytes in Cardiovascular Disease.
Adamo L, Rocha-Resende C, Mann DL.Annu Rev Immunol. 2020 Apr 26;38:99-121. doi: 10.1146/annurev-immunol-042617-053104.PMID: 32340574
Pirfenidone is a cardioprotective drug: Mechanisms of action and preclinical evidence.
Aimo A, Cerbai E, Bartolucci G, Adamo L, Barison A, Lo Surdo G, Biagini S, Passino C, Emdin M.Pharmacol Res. 2020 May;155:104694. doi: 10.1016/j.phrs.2020.104694. Epub 2020 Feb 19.PMID: 32061664
Reappraising the role of inflammation in heart failure.
Adamo L, Rocha-Resende C, Prabhu SD, Mann DL.Nat Rev Cardiol. 2020 May;17(5):269-285. doi: 10.1038/s41569-019-0315-x. Epub 2020 Jan 22.PMID: 31969688 Review.
Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart.
Adamo L, Rocha-Resende C, Lin CY, Evans S, Williams J, Dun H, Li W, Mpoy C, Andhey PS, Rogers BE, Lavine K, Kreisel D, Artyomov M, Randolph GJ, Mann DL.JCI Insight. 2020 Feb 13;5(3):e134700. doi: 10.1172/jci.insight.134700.PMID: 31945014
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
Adamo L, Yu J, Rocha-Resende C, Javaheri A, Head RD, Mann DL. Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction. J Am Coll Cardiol. 2020 Oct 27;76(17):1982-1994. doi: 10.1016/j.jacc.2020.08.061. PMID: 33092734; PMCID: PMC7584807.
- Immunomodulatory role of non-neuronal cholinergic signaling in myocardial injury.
Rocha-Resende C, Weinheimer C, Bajpai G, Adamo L, Matkovich SJ, Schilling J, Barger PM, Lavine KJ, Mann DL.JCI Insight. 2019 Jun 4;5(14):e128961. doi: 10.1172/jci.insight.128961.PMID: 31162139
- Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury.
Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL.JCI Insight. 2018 Jun 7;3(11):e120137. doi: 10.1172/jci.insight.120137. eCollection 2018 Jun 7.PMID: 29875326
Let's Do This Together!
If you are interested in the relationship between the immune system and the heart… we have something in common, and we would like to hear from you! Our team is growing. We have open positions for post-docs, staff scientists, technicians, graduate students and undergraduate students. In addition, we are open to any form of collaboration, in both the clinical and laboratory setting.