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School of Medicine
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Biology of Healthy Aging Program
Studies within this group range from molecular and cellular to genetic and laboratory animal-based approaches targeted to understanding the mechanisms, risk factors, and pathophysiology of aging-related changes in health, function, and quality of life.
In addition, the faculty and staff involved in this interdisciplinary program has considerable expertise in the development of clinical translational studies in human populations, epidemiological studies in populations of older adults, and in clinical intervention trials.
The major aims of this group are to:
- Investigate etiologies for age-related activation in inflammatory and renin-angiotensin system pathways and their consequences on the development of frailty, sarcopenia, cognitive decline, osteopenia, and other chronic diseases of older adults.
- Develop treatments that focus on inflammation and angiotensin system activation and their consequences
- Investigate the viral-related causes and treatments for immunosenescence in older adults, and develop treatments for these etiologies.
- Develop novel vaccination strategies for frail older adults for influenza and CMV.
- Study the etiologies and consequences of aging-related changes in mitochondria on health and well being.
- Develop and validate physiotypes of frailty and robust health in older adults by integrating genetic, cellular, and clinical level phenomena into integrative biological models
- Translate novel aging-related biological findings into diagnostic tests, novel treatments, and preventive strategies that will help to optimize quality of life and healthy aging.