Shawn Lupold Laboratory
The Lupold Laboratory is a basic and translational research laboratory focused on the molecular biology of prostate cancer. Our mission is to define the molecular mechanisms that contribute to lethal prostate cancer for the development of new diagnostic, prognostic and therapeutic strategies.
Our research areas of interest include major interests include microRNAs, RNA therapeutics and high-throughput screening approaches.
The Shawn Lupold Laboratory is a highly collaborative group. Our team values multidisciplinary interactions and projects.
Shawn Lupold, Ph.D., is professor of urology and oncology at the Johns Hopkins School of Medicine and co-director of the Prostate Cancer Group for the Sidney Kimmel Comprehensive Cancer Center.
Polina Sysa-Shah, Ph.D., Sr. Research Specialist
Alok Mishra, Ph.D., Research Associate
Akira Kurozumi, M.D., Ph.D., Postdoctoral Fellow
Shireen Chikara, Ph.D., Postdoctoral Fellow
Previous Lab Members
Undergraduate and Summer Students
Mark Castanares, Ph.D.
Thiago Martin, Ph.D.
Binod Kumar, Ph.D.
Kenji Zennami, M.D., Ph.D.
Koji Hatano, M.D., Ph.D.
Amarnath Mukherjee, Ph.D.
Xiaohua Ni, Ph.D.
Fatema Rafiqi, Ph.D.
Judit Ribas, Ph.D.
Ping Wu, M.D., Ph.D.
News and UpdatesAndrogen Signaling Regulates the PDCD4 Tumor Suppressor Gene
In the February 2019 issue of Molecular Cancer Research, Kenji Zennami reports that androgen receptor signaling leads to the suppression of PDCD4 mRNA and protein expression through the induction of miR-21 expression. In cell and tumor models of prostate cancer, Kenji found PDCD4 knockdown to enhance cell proliferation, reduce apoptosis, augment tumorigenesis and drive castration resistance. He also found, through collaboration with Luigi Marchionni, that high Gleason grade prostate cancers exhibit low levels of PDCD4 mRNA and high levels of miR-21.
Our team works closely with laboratories and investigators across Johns Hopkins Medicine to foster discovery. Learn more about our collaborative work and the researchers we’ve teamed up with to tackle prostate cancer.
Other Facilities & Sites
- Brady Urological Institute
- Giving to the Brady Urological Institute
- The Sidney Kimmel Comprehensive Cancer Center
- The Prostate Cancer Program at the Sidney Kimmel Comprehensive Cancer Center
- The Johns Hopkins Program for microRNA biology
- Johns Hopkins University Oncology Tissue Services
- Prostate Cancer Biorepository Network (PCBN)
- Prostate Cancer Foundation
- Society for Basic Urologic Research
- American Association for Cancer Research
- Movember Foundation