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Neurodegenerative and neurodevelopmental diseases, stroke and traumatic brain injury are devastating conditions. The development of new treatment relies on coaxing remaining cells in the brain and nervous system to repair and replace injured or damaged cells. The Neuroregeneration program at ICE (NeuroICE) investigates a broad range of research topics to push the field faster and closer toward clinical treatments. To this end, NeuroICE researchers study neuroregeneration, neuronal cell death and survival, cell fate specification, embryonic and adult stem cells, synapse formation, axonal and dendritic targeting, neuronal development, and regulation of gene expression. The work is relevant to many disorders of the nervous system including autism and schizophrenia, major depression, bipolar disease, Parkinson’s disease, stroke, peripheral nerve disease and chronic pain.
The Neuroregeneration Program at Johns Hopkins’ Institute for Cell Engineering
Researcher Valina Dawson introduces the Neuroregeneration Program, where scientists study causes and potential treatments for conditions such as Parkinson’s and stroke.
- Shaida Andrabi, Ph.D.
- Seth Blackshaw, Ph.D.
- Ted Dawson, M.D., Ph.D.
- Valina Dawson, Ph.D., Director
- Han Seok Ko, Ph.D.
- Gabsang Lee, D.V.M., Ph.D.
- Guo-li Ming, M.D., Ph.D.
- Jonathan Schneck, M.D., Ph.D.
- Gregg Semenza, M.D., Ph.D.
- Hongjun Song, Ph.D.
Neurons Constantly Rewrite Their DNA
Johns Hopkins scientists have discovered that neurons are risk takers: They use minor “DNA surgeries” to toggle their activity levels all day, every day.
Stem Cells Reveal How Illness-Linked Genetic Variation Affects Neurons
A genetic variation linked to schizophrenia, bipolar disorder and severe depression wreaks havoc on connections among neurons in the developing brain, a team of researchers reports.
Schizophrenia-Associated Gene Variation Affects Brain Cell Development
Johns Hopkins researchers have begun to connect the dots between a schizophrenia-linked genetic variation and its effect on the developing brain.
New Type Of Protein Action Found To Regulate Development
Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development.
Researchers Pinpoint Protein Crucial For Development Of Biological Rhythms In Mice
Johns Hopkins researchers report that they have identified a protein essential to the formation of the tiny brain region in mice that coordinates sleep-wake cycles and other so-called circadian rhythms.