Neurodegenerative diseases and traumatic brain injury are devastating conditions. The hope in future treatment lies in the hope of coaxing remaining cells in the brain and nervous system to repair and replace injured or damaged cells. Also known as NeuroICE, the Neuroregeneration program at ICE leads programs in a broad range of research topics that aims to push the field faster and closer toward clinical treatments. To this end, NeuroICE researchers study neuroregeneration, neuronal cell death and survival, apoptosis, cell fate specification, embryonic and adult stem cells, synapse formation, axonal and dendritic targeting, neuronal development, gene expression and the molecular biology of Parkinson’s disease, stroke and vision.
Stem Cells Reveal How Illness-Linked Genetic Variation Affects Neurons
A genetic variation linked to schizophrenia, bipolar disorder and severe depression wreaks havoc on connections among neurons in the developing brain, a team of researchers reports.
Schizophrenia-Associated Gene Variation Affects Brain Cell Development
Johns Hopkins researchers have begun to connect the dots between a schizophrenia-linked genetic variation and its effect on the developing brain.
New Type Of Protein Action Found To Regulate Development
Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development.
Researchers Pinpoint Protein Crucial For Development Of Biological Rhythms In Mice
Johns Hopkins researchers report that they have identified a protein essential to the formation of the tiny brain region in mice that coordinates sleep-wake cycles and other so-called circadian rhythms.
Getting To The Root Of Parkinson's Disease
Working with human neurons and fruit flies, researchers at Johns Hopkins have identified and then shut down a biological process that appears to trigger a particular form of Parkinson’s disease present in a large number of patients.