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William B. Guggino Lab

William Guggino, Ph.D.

Principal Investigator:
William Guggino, Ph.D.

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Work in the William B. Guggino Lab focuses on the structure of the cystic fibrosis transmembrane conductance regulator (CFTR) and water channels; the molecular structure of transport proteins in epithelial cell membranes; and gene therapies to treat cystic fibrosis (CF) patients. We are also working to identify CF’s specific defect in chloride channel regulation. One recent study showed that insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR.

Research Areas: cell biology, cystic fibrosis, kidney diseases, gene therapy, ion channels

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