Basic science investigations in the Umapathi Lab focus on understanding how metabolic dysregulation drives heart failure and cardiomyopathy. The laboratory employs patient-derived induced pluripotent stem cell (iPSC) models, transgenic mouse systems, and advanced proteomics to define the molecular mechanisms underlying metabolic heart failure (MetHF), with particular emphasis on O-GlcNAcylation and cardiac energetics in heart failure. Additional research explores the mechanistic basis of contractile dysfunction/arrhythmias in inherited cardiomyopathies, particularly LMNA-related disease, integrating calcium signaling, mechanobiology, and electrophysiology to identify novel therapeutic targets for conduction abnormalities and ventricular arrhythmias.