Principal Investigator:
Seth Margolis, Ph.D.
Department:
Biological Chemistry
The Seth Margolis Laboratory studies the signaling pathways that regulate synapse formation during normal brain development to try to understand how, when these pathways go awry, human cognitive disorders develop. We use Ephexin5 to study the molecular pathways that regulate restriction of excitatory synapse formation and their relevance to the pathophysiology of Angelman syndrome.
Research Areas: cognition, Angelman syndrome, human development, cellular signaling, synapse formation