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Follow the Leader: Specialized Cancer Cells Lead Collective Invasion (Ewald Lab)

Andrew Ewald, Ph.D.

Principal Investigator:
Andrew Ewald, Ph.D.
Cell Biology

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Research in the Ewald laboratory starts from a simple question: Which cells in a breast tumor are the most dangerous to the patient and most responsible for metastatic disease? To answer this question, we developed novel 3-D culture assays to allow real-time analysis of invasion. Our data reveal that K14+ cancer cells play a central role in metastatic disease and suggest that the development of clinical strategies targeting these cells will provide novel breast cancer treatments.

Research Areas: breast cancer, cellular biology, molecular biology

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