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Science: Out of the Box

Immunotherapy and Antibodies | Slaying Lung Cancer

Medical oncologist Julie Brahmer, M.D., explains how immunotherapy works as a tool in treating lung cancer. Using toys and finger paints, she demonstrates how the immune system attacks cancer cells. Dr. Brahmer discusses why immunotherapy is a promising new treatment that can extend lives in certain cases, helping some people with lung cancer live longer and better lives.

Blocking Cancer's Path - Science Out of the Box

Johns Hopkins researcher Sandra Gabelli talks about how better understanding the structure of enzyme PI3K could one day aid the fight against cancer.


Magnetizing Cells for Tracking - Science Out of the Box

Although it has great potential for treating cancer, spinal cord injuries, diabetes and many other serious diseases, there are challenges to making stem cell therapy a reality. Watch cell imaging specialist Jeff Bulte explain his pioneering work in tracking stem cells in the body — and how it can help lead to better stem cell treatments by reporting stem cells’ location and whether they are still alive.


Regenerating Neurons | Science: Out of the Box

For a long time, scientists thought that brain and spinal cord cells, once damaged, could not be fixed. But that may not be true. Watch neuroscientist David Linden explain how some nerve cells can repair themselves.


Driving Toward a Cure for ALS | Science: Out of the Box

Johns Hopkins neurologist Jeffrey Rothstein explains how sticky DNA causes ALS. He shows how one drug he identified works to de-stick the DNA so it no longer globs up proteins in the cell.

Understanding Ubiquitin | Science: Out of the Box

Johns Hopkins biophysicist Cynthia Wolberger explains how the small protein ubiquin regulates many events in the cell including turning off and on genes.


Epigenetics: A Symphony of Discovery | Science: Out of the Box

Johns Hopkins Kimmel Cancer Center Director Bill Nelson discusses epigenetics with help from the musicians from the Peabody Institute.

Battling Cancer Using Epigenetics | Science: Out of the Box

Johns Hopkins surgeon and oncologist Malcolm Brock explains how we can fight cancer using epigenetic therapies. The epigenetic drug treatment changes cancer cells to be more like healthy cells, making them more susceptible to traditional cancer therapies like chemotherapy.

Understanding Niche Cells | Science: Out of the Box

Johns Hopkins cell biologist Erika Matunis explains how understanding the cells that take care of stem cells may shed light on cancer.

Programming Cancer Cells to Self-Destruct | Science: Out of the Box

Johns Hopkins biomedical engineer Jordan Green talks about a goal of his research: making nanoparticles that could program cancer cells to self-destruct.

Muscling DNA Around Using Protein Nanomachines | Science: Out of the Box

Johns Hopkins biophysicist James Berger explains why he studies the nanomachines that pry apart and untangle DNA.

Building Stronger Brain Cell Connections | Science: Out of the Box

Johns Hopkins' neuroscientist Mollie Meffert explains how brain cells use microRNAs to grow new connections to "talk" to each other and store memories.

Stopping Breast Cancer Leader Cells

Johns Hopkins’ cell biologist Andy Ewald explains his latest finding on how breast cancer cells spread and how they might be stopped.