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Zebrafish in Prescott Lab Work to Knock Out Thyroid Cancer

Zebrafish in Prescott Lab Work to Knock Out Thyroid Cancer

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The Researcher

Name: Jason Prescott, M.D., Ph.D.
Title: Assistant Professor of Surgery and of Oncology, Director of Thyroid and Parathyroid Surgery
Years at Johns Hopkins: 6

The Research

Interests and Goals:

  • Dissecting the subcellular molecular changes that turn a normal thyroid cell into a cancer cell and identifying new therapeutics targeting these changes.
  • Using transgenic zebrafish and human cell lines, Prescott and his lab team are developing high-throughput screening systems for identification of new anti-thyroid cancer drugs. 

Main Grants: 

  • The Johns Hopkins Ross Physician Scientist Endowment
  • The American Thyroid Association
  • The American Association of Endocrine Surgeons

Highlights of Zebrafish Research:

Developed a number of live transgenic fish with fluorescent thyroids for use in studies of both normal thyroid development and of thyroid cancer development.  

Recent Advancements:

Developing transgenic zebrafish needed to perform high-throughput screening for new anti-thyroid cancer drugs.

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