Genetic Medicine Pioneer

Published in Hopkins Medicine - Spring/Summer 2023

Barbara Migeon, trailblazing pioneer and professor emeritus in genetic medicine at the Johns Hopkins University School of Medicine, died Jan. 14. She was 91.

Migeon was the sixth woman to reach the rank of professor at the Johns Hopkins University School of Medicine.

She is known for pioneering genetics work in sex determination. Specifically, Migeon focused on the molecular basis of X inactivation — the process in which one of a female’s two X chromosomes is inactivated.

Migeon also studied the health and disease consequences of X inactivation — including mosaicism — and in 1980, she successfully cloned fragments of the human X chromosome.

“Barbara worked at Johns Hopkins during the early days of the genetic medicine field, and she has left a legacy of teaching and research that will continue to be the foundation for current and future geneticists and scientists,” says Ambroise Wonkam, director of the McKusick-Nathans Institute and the Department of Genetic Medicine at the Johns Hopkins School of Medicine.

A graduate of Smith College and the University of Buffalo medical school, Migeon completed an internship and residency in the Johns Hopkins pediatrics department and a genetics fellowship under the direction of Johns Hopkins geneticist Barton Childs. In 1963, she became an instructor in the pediatrics department, and she continued as a member of the faculty until 2020.

Migeon is the founding director of the school of medicine’s human genetics graduate program. She mentored scores of medical students, graduate students and researchers, even beyond her retirement, and she published extensively about her research, including the book Females Are Mosaics: X Inactivation and Sex Differences in Disease and its second edition, which is considered the definitive review of the field.

Migeon received the 2016 March of Dimes/Colonel Harland D. Sanders Lifetime Achievement Award in Genetics. Her husband, Claude Migeon, who died in 2018, directed the division of pediatric endocrinology at Johns Hopkins from 1961 to 1994.

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