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Neurology and Neurosurgery

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Spine Center Clinical Trials

If you would like to participate in a clinical trial at Johns Hopkins, please go to the  clinical trial database (ITCR), for more information.

Study Title: NA_00023202

Principal Investigator: Chetan Bettagowda, MD

Summary: Physicians at the Johns Hopkins Hospital are participating in a FDA approved clinical trial that is testing a novel therapy for patients with recurrent chordoma, a rare spine tumor.

C. novyi-NT is currently in an FDA sanctioned phase I clinical trial at the Johns Hopkins Hospital. Chordomas are thought to be very hypoxic and this could be part of the reason why standard chemotherapies have historically failed in chordoma patients. We are currently enrolling patients to understand how people with recurrent chordomas arising in the sacrum respond to this therapy.

Recruiting Status: Open

For more information, please contact Dr. Charles Rudin at 410.955.8893

Learn about Hypoxia Targeting Therapy for Chordomas

Study Title: NA_00036459: CSSG Multi Center Retrospective and Observational Data Registry for Clinical and Radiographic Outcomes of Complex Spine Surgeries

Principal Investigator: Daniel Sciubba, MD

Summary: The purpose of this study is to collect information for a research database from subjects with spinal disease and deformity. This will be called the “Complex Spine Study Group (CSSG) Database.” This database will be used to help with research in the future.

The Complex Spine Study Group database is designed to develop a better understanding of spinal disease and deformities, and how they have responded to various forms of treatment and interventions. Spinal disease and deformities are caused by many different conditions, but involve abnormal alignment of the spine.

Recruiting Status: Open

Study Title: NA_00048835: National Neurosurgery Quality and Outcomes Database (N2QOD)

Principal Investigator: Ali Bydon, MD

Summary: To date, no nationally collaborative reporting mechanisms utilizing validated quality and outcome measures have assessed 1) to what extent lumbar spinal surgery improves pain, disability, and quality of life and 2) what incidence of morbidity is acceptable after lumbar surgery adjusting for biasing and influential confounders; including variances in co-morbidity, surgical approach, cultural, region, structure and process of health services. Hence, risk-adjusted benchmarks of surgical morbidity and effectiveness, which define spine surgical quality, have yet to be determined. Without a robust quality improvement networking platform, benchmarks of acceptable quality of care cannot be accurately assessed and practice groups cannot accurately determine areas of their practice where quality improvement should be targeted.

Recruiting Status: Open


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Maryland Patients

Learn how to request an appointment with or refer a patient to the Neurosurgical Spine Center at Johns Hopkins. You may direct additional questions or follow up with one of our office coordinators at 410-955-4424.

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