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The Sidney Kimmel Comprehensive Cancer Center

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Bone Marrow Failure Disorders Program

At the Center for Bone Marrow Failure Disorders at the Johns Hopkins Kimmel Cancer Center, our goal is to give patients prompt, accurate diagnoses and the latest available treatments for these complex, rare conditions.

Bone marrow failure syndromes are rare diseases characterized by an inability to make enough blood – either red cells, which carry oxygen; white cells, which fight infection; or platelets, which help the blood clot. Bone marrow failure disorders may be either inherited or acquired.

Johns Hopkins’ hematology and oncology experts have a long history and broad experience in managing these challenging disorders. It was a researcher at Johns Hopkins who first established regimens more than 40 years ago that would lead to bone marrow transplantation -- the process of taking marrow from a healthy donor and injecting it into a patient. Our multidisciplinary team has improved on the process over time. Recent advances in so-called haploidentical, or half-matched, bone marrow transplantation have allowed for a much broader range of donors, allowing just about any patient to be eligible for the procedure. This means a donor can be found for nearly every patient who needs a bone marrow transplant to be cured. In addition, new regimens with high-dose cyclophosphamide – with or without bone marrow transplantation – have “cured” many patients with autoimmune disorders such as aplastic anemia. For more information about our Bone Marrow Transplant Program.

Our multidisciplinary team spends time seeing patients in the center and researching new therapies in the lab. We participate in many local and national clinical trials.