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Wu Lab

 Principal Investigator: Katherine Wu, M.D.

Dr. Wu leads a multi-disciplinary team with collaborators from the Bloomberg School of Public Health, JHU Whiting School of Engineering, and JHU Krieger School of Arts and Sciences.  She conducts ongoing investigations with the Multicenter AIDS Cohort Study and Women’s Inter-agency Health Study. Her lab’s goals are to develop, implement, and validate novel imaging-based metrics of cardiac structure and function to improve risk prediction and stratification at the individual patient-level.

Research Focus

  • Predictors of Sudden Cardiac Death by Magnetic Resonance Imaging
  • Subclinical myocardial disease in people living with HIV
  • Individualized risk prediction
  • Cardiac structural and mechanical modeling

Active Projects

  • Identifying risk factors for subclinical myocardial disease in HIV infection
  • Cardiac MR to Improve Clinical Risk Prediction in Defibrillator Patients
  • Novel Methods for Non-Invasive Assessment of Myocardial Fibrosis Complexity and Disorganization to Predict Ventricular Arrhythmias
  • Understanding clinical and subclinical predictors, biomarkers and pathogenesis of chronic diseases in HIV-infected men who have sex with men (MSM) as compared to HIV-uninfected MSM: Ambulatory EKG and Echo Core Lab
  • Personalized Risk Stratification for Sudden Cardiac Death Using Cardiac MRI and Virtual Heart Electrophysiologic Studies (PuRSUit-Virtual Heart) in Ischemic and Non-ischemic Cardiomyopathy

Collaborators

Funding Support

  • NIH/NHLBI
  • Johns Hopkins Discovery Award Program
  • Johns Hopkins inHealth Pilot Project Discovery Program   

Selected Bibliography

  • Tao S, Ashikaga H, Ciuffo LA, Yoneyama K, Lima JAC, Frank TF, Weiss RG, Tomaselli GF, Wu KC.  Impaired left atrial function predicts inappropriate shocks in primary prevention implantable cardioverter-defibrillator candidates.  J Cardiovasc Electrophysiol 2017;28(7):796-805.
  • Zhang Y, Guallar E, Weiss RG, Stillabower M, Gerstenblith G, Tomaselli GF, Wu KC. Associations between scar characteristics by cardiac magnetic resonance and changes in left ventricular ejection fraction in primary prevention defibrillator recipients. Heart Rhythm 2016; 13(8):1661-6
  • Arevalo HJ, Vadakkumpadan F, Guallar E, Jebb A, Malamas P, Wu KC, Trayanova NA.  Arrhythmia risk stratification after myocardial infarction using personalized heart models. Nat. Commun. 2016;7:11437.
  • Strauss DG, Loring Z, Selvester RH, Gerstenblith G, Tomaselli GF, Weiss RG, Wagner GS, Wu KC. Right, but not left, bundle branch block is associated with large anteroseptal scar. J Am Coll Cardiol 2013; 62(11):959-67. 
  • Loring Z, Strauss DG, Gerstenblith G, Tomaselli GF, Weiss RG, Wu KC. Cardiac MRI scar patterns differ by gender in an implantable cardioverter defibrillator and cardiac resynchronization therapy cohort. Heart Rhythm 2013; 10(5):659-65. 
  • Wu KC, Gerstenblith G, Guallar E, Marine JE, Dalal D, Cheng A, Marbán E, Lima JAC, Tomaselli GF, Weiss RG. Combined cardiac MRI and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging  2012; 5:178-86.
  • Strauss DG, Cardoso S, Lima JAC, Rochitte CE, Wu KC. ECG scar quantification correlates with cardiac magnetic resonance scar size and prognostic factors in Chagas’ disease. Heart 2011; 97(5):357-61.
  • Strauss DG, Poole JE, Wagner GS, Selvester RH, Miller JM, Anderson J, Johnson G, McNulty SE, Mark DB, Lee KL, Bardy GH, Wu KC.  An ECG index of myocardial scar enhances prediction of defibrillator shocks: An analysis of the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Heart Rhythm  2011; 8(1):38-45.
  • Strauss DG, Selvester RH, Lima JA, Arheden H, Miller JM, Gerstenblith G, Marbán E, Weiss RG, Tomaselli GF, Wagner GS, Wu KC.  ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis.  Circ Arrhythm Electrophysiol  2008; 1:327-36.
  • Wu KC, Weiss RG, Thiemann DR, Kitagawa K, Schmidt A, Dalal D, Lai S, Bluemke DA, Gerstenblith G, Marbán E, Tomaselli GF, Lima JAC.  Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol 2008;51: 2414-21.
  • Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, Gerstenblith G, Weiss RG, Marban E, Tomaselli GF, Lima JA, Wu KC.  Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction.  Circulation 2007;115:2006-14.
  • Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005;352:539-48.
  • Wu KC, Kim RJ, Bluemke DA, Rochitte CE, Zerhouni EA, Becker LC, Lima JAC.  Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion. J Am Coll Cardiol 1998;32:1756-64.
  • Wu KC, Zerhouni EA, Judd RM, Lugo-Olivieri CH, Barouch LA, Schulman SP, Blumenthal RB, Lima JAC.  The prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation 1998;97:765-72.
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