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Ciccarone Articles

Ciccarone Center Research


Vascular Imaging

Landmark Article

Risk factor differences for aortic versus coronary calcified atherosclerosis. The Multiethnic Study of Atherosclerosis.
By: Criqui MH, Kamineni A, Allison MA, Ix JH, Carr JJ, Cushman M, Detrano R, Post W, Wong ND.
Abdominal aortic calcium (AAC) showed stronger correlations with most CVD risk factors than did CAC. The predictive value of AAC compared with CAC for incident CVD events remains to be evaluated.
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Thoracic aortic distensibility and thoracic aortic calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]).
By: Al-Mallah MH, Nasir K, Katz R, Takasu J, Lima JA, Bluemke DA, Hundley G, Blumenthal RS, Budoff MJ.
Using multivariate analysis, thoracic aortic calcification (TAC) was independently associated with aortic distensibility (AD) after adjusting for age, gender, ethnicity, and other covariates. Our analysis demonstrated that increased arterial stiffness is associated with increased TAC, independent of ethnicity and other atherosclerotic risk factors.
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Images in vascular medicine: Giant iliac artery aneurysms.
By: Ratchford EV, Black JH.
A common iliac artery aneurysm is defined as a 50% increase in diameter compared with the normal artery and typically occurs in conjunction with an abdominal aortic aneurysm (AAA), as seen in this case. The majority result from degenerative atherosclerosis, and patients are most often asymptomatic. While open surgery with a prosthetic graft has been the traditional therapy, endovascular repair has emerged as the treatment of choice for common iliac artery aneurysms with suitable anatomy.
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Left ventricular structure and function in patients with rheumatoid arthritis, as assessed by cardiac magnetic resonance imaging.
By: Giles JT, Malayeri AA, Fernandes V, Post W, Blumenthal RS, Bluemke D, Vogel-Claussen J, Szklo M, Petri M, Gelber AC, Brumback L, Lima J, Bathon JM.
Heart failure is a major contributor to cardiovascular morbidity and mortality in patients with RA, but little is known about myocardial structure and function in this population. This study suggests that the progression to heart failure in RA may occur through reduced myocardial mass rather than hypertrophy. Both modifiable and nonmodifiable factors may contribute to lower levels of left ventricular mass and volume.
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Increased prevalence of carotid artery atherosclerosis in rheumatoid arthritis is artery-specific.
By: Kobayashi H, Giles JT, Polak JF, Blumenthal RS, Leffell MS, Szklo M, Petri M, Gelber AC, Post W, Bathon JM.
Compared to controls, RA was associated with a higher prevalence and higher severity of atherosclerosis in the bulb-ICA but not the CCA. Our data suggest that future studies in RA that utilize carotid artery measurements should include assessment of the bulb-ICA.
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Relationship between common carotid intima-media thickness and thoracic aortic calcification: the Multi-Ethnic Study of Atherosclerosis.
By: Takasu J, Budoff MJ, Katz R, Rivera JJ, Shavelle DM, Probstfield JL, O’Leary D, Nasir K.
Mean maximum carotid intima-media thickness (CIMT) is associated with both coronary artery disease and cerebral thromboembolism. Thoracic aortic calcification (TAC) detected by computed tomography (CT) is also highly associated with vascular disease and cardiovascular risk. No previous study has examined the relationship between CIMT and TAC in a large patient cohort. We performed a cross-sectional study to determine whether, at baseline, there is a relationship between CIMT and CT-determined TAC score.
Our study demonstrates that TAC is associated with increasing severity of carotid atherosclerotic burden as measured by CIMT. The combined utility of these two noninvasive measures of subclinical atherosclerosis for CVD risk assessment needs to be determined in future studies.
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Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis.
By: Naj AC, West M, Rich SS, Post W, Kao WH, Wasserman BA, Herrington DM, Rodriguez A.
Little is known about the association of scavenger receptor class B type I (SCARB1) single-nucleotide polymorphisms (SNPs) and subclinical atherosclerosis, particularly in subjects of different racial/ethnic backgrounds. We examined this relationship in the Multi-Ethnic Study of Atherosclerosis and found that variation in SCARB1 at rs10846744 was significantly associated with common carotid intimal-medial artery thickness across racial/ethnic groups.
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Carotid bruit for detection of hemodynamically significant carotid stenosis: the Northern Manhattan Study.
By: Ratchford EV, Jin Z, Di Tullio MR, Salameh MJ, Homma S, Gan R, Boden-Albala B, Sacco RL, Rundek T.
In this ethnically diverse cohort, the prevalence of carotid bruits and hemodynamically significant carotid stenosis was low. Sensitivity and positive predictive value were also low, and the 44% false-negative rate suggests that auscultation is not sufficient to exclude carotid stenosis. While the presence of a bruit may still warrant further evaluation with carotid duplex, ultrasonography may be considered in high-risk asymptomatic patients, irrespective of findings on auscultation.
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