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Ciccarone Articles

Ciccarone Center Research



Landmark Articles

Coronary artery calcium for the prediction of mortality in young adults <45 years old and elderly adults >75 years old.
By: Tota-Maharaj R, Blaha MJ, McEvoy JW, Blumenthal RS, Muse ED, Budoff MJ, Shaw LJ, Berman DS, Rana JS, Rumberger J, Callister T, Rivera J, Agatston A, Nasir K.
The value of coronary artery calcium for predicting mortality extends to both elderly patients and those <45 years old. Elderly persons with no CAC have a lower mortality rate than younger persons with high CAC.
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Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis.
By: Champaneri S, Xu X, Carnethon MR, Bertoni AG, Seeman T, Diez Roux A, Golden SH.


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Gender differences in coronary plaque composition and burden detected in symptomatic patients referred for coronary computed tomographic angiography.
By: Qureshi W, Blaha MJ, Nasir K, Al-Mallah MH.
Symptomatic women have a lower prevalence of obstructive coronary artery disease and are less likely to have mixed coronary plaque compared to symptomatic men. Future studies are needed to determine the prognostic implications of these findings.
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Interplay of coronary artery calcification and traditional risk factors for the prediction of all-cause mortality in asymptomatic individuals.
By: Nasir K, Rubin J, Blaha MJ, Shaw LJ, Blankstein R, Rivera JJ, Khan AN, Berman D, Raggi P, Callister T, Rumberger JA, Min J, Jones SR, Blumenthal RS, Budoff MJ.
Current guidelines recommend the use of coronary artery calcification (CAC) scoring for intermediate risk patients; however, the potential role of CAC among individuals who have no risk factors is less established. We sought to examine the relationship between the presence and burden of traditional risk factors and CAC for the prediction of all-cause mortality. By highlighting that individuals without risk factors but elevated CAC have substantially higher event rates than those that have multiple risk factors but no CAC, these findings challenge the exclusive use of traditional risk assessment algorithms for guiding the intensity of primary prevention therapies.
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Coronary computed tomographic angiography and risk of all-cause mortality and nonfatal myocardial infarction in subjects without chest pain syndrome from the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International...
By: Cho I, Chang HJ, Sung JM, Pencina MJ, Lin FY, Dunning AM, Achenbach S, Al-Mallah M, Berman DS, Budoff MJ, Callister TQ, Chow BJ, Delago A, Hadamitzky M, Hausleiter J, Maffei E, Cademartiri F, Kaufmann P, Shaw LJ, Raff GL, Chinnaiyan KM, Villines TC, Cheng V, Nasir K, Gomez M, Min JK; on behalf of the CONFIRM Investigators.

Although the prognosis for individuals without chest pain is stratified by coronary computed tomographic angiography (cCTA), the additional risk-predictive advantage by cCTA is not clinically meaningful compared with a risk model based on coronary artery calcium scoring. Therefore, at present, the application of cCTA for risk assessment of individuals without coronary artery calcium scoring should not be justified.

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Interplay of coronary artery calcification and traditional risk factors for the prediction of all-cause mortality in asymptomatic individuals.
By: Nasir K, Rubin J, Blaha MJ, Shaw LJ, Blankstein R, Rivera JJ, Khan A, Berman D, Raggi P, Callister T, Rumberger J, Min J, Jones SR, Blumenthal RS, Budoff MJ.
While both risk factors and CAC were associated with increasing CVD risk, CAC provides classification across a wider range of risk levels than traditional risk factors alone. Even among individuals with no risk factors, increased CAC is associated with a significantly higher CVD risk. While the absence of CAC is associated with very low intermediate term mortality, individuals with no risk factors but severe CAC have a high event rate.
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Waiting for the National Cholesterol Education Program Adult Treatment Panel IV Guidelines, and in the Meantime, Some Challenges and Recommendations.
By: Martin SS, Metkus TS, Horne A, Blaha MJ, Hasan R, Campbell CY, Yousuf O, Joshi P, Kaul S, Miller M, Michos ED, Jones SR, Gluckman TJ, Cannon CP, Sperling LS, Blumenthal RS.
The National Cholesterol Education Program Adult Treatment Panel (ATP) has provided education and guidance for decades on the management of hypercholesterolemia. Its third report (ATP III) was published 10 years ago, with a white paper update in 2004. There is a need for translation of more recent evidence into a revised guideline. To help address the significant challenges facing the ATP IV writing group, this statement aims to increase the likelihood of implementation in clinical practice by offering solutions that translate the totality of published reports into enhanced hyperlipidemia guidelines to better combat the devastating impact of hyperlipidemia on cardiovascular health.
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Lipid parameters and cardiovascular events in patients taking statins.
By: Martin SS, Jones SR.
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Vitamin D for the prevention of stroke incidence and disability: Promising but too early for prime time.
By: Michos ED, Gottesman RF.
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Comparative effectiveness and safety of methods of insulin delivery and glucose monitoring for diabetes mellitus: A systematic review and meta-analysis.
By: Yeh HC, Brown TT, Maruthur N, Ranasinghe P, Berger Z, Suh YD, Wilson LM, Haberl EB, Brick J, Bass EB, Golden SH.
Continuous subcutaneous insulin infusion and multiple daily injections have similar effects on glycemic control and hypoglycemia, except continuous subcutaneous insulin infusion has a favorable effect on glycemic control in adults with type 1 diabetes mellitus. For glycemic control, real-time continuous glucose monitoring is superior to self-monitoring of blood glucose, and sensor-augmented insulin pumps are superior to multiple daily injections and self-monitoring of blood glucose without increasing the risk for hypoglycemia.
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