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Ciccarone Articles

Ciccarone Center Research

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Diet & Weight

Landmark Articles

Vegetarian diets in cardiovascular prevention.
By: Ashen MD, Blumenthal RS, Sperling L.
This article reviews the strengths and limitations of the various types of vegetarian diets and variations of them.
A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care?
By: Oni ET, Agatston AS, Blaha MJ, Fialkow J, Cury R, Sposito A, Erbel R, Blankstein R, Feldman T, Al-Mallah MH, Santos RD, Budoff MJ, Nasir K.

Considerable evidence supports the association of nonalcoholic fatty liver disease with subclinical atherosclerosis, independent of traditional risk factors and metabolic syndrome.

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Relation of hepatic steatosis to atherogenic dyslipidemia.
By: Makadia S, Blaha MJ, Keenan T, Ndumele C, Jones S, DeFilippis A, Martin SS, Kohli P, Conceicao RD, Carvalho JA, Nasir K, Blumenthal RS, Santos R.
This article looks at the relationship between fatty liver and atherogenic lipid profiles.
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Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association.
By: Bays HE, Toth PP, Kris-Etherton PM, Abate N, Aronne LJ, Brown WV, Gonzalez-Campoy JM, Jones SR, Kumar R, La Forge R, Samuel VT.
The goal of this statement is to better define the effect of adiposity on lipoproteins, how the pathos of excessive body fat (adiposopathy) contributes to dyslipidemia, and how therapies such as appropriate nutrition, increased physical activity, weight-management drugs, and bariatric surgery might be expected to impact dyslipidemia.
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Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: Results from MESA.
By: Ahmed HM, Blaha MJ, Nasir K, Jones SR, Rivera JJ, Agatston A, Blankstein R, Wong ND, Lakoski S, Budoff MJ, Burke GL, Sibley CT, Ouyang P, Blumenthal RS.
Unhealthy lifestyle habits are a major contributor to coronary artery disease (CAD). The purpose of the study was to investigate the associations of smoking, weight maintenance, physical activity, and Mediterranean-style diet with coronary calcium, cardiovascular events, and mortality. We discovered that, over the course of nearly 8 years, a combination of regular exercise, healthy diet, smoking avoidance, and weight maintenance contributed to lower coronary calcium incidence, slower calcium progression, and lower all-cause mortality.
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Sex steroid levels and response to weight loss interventions among postmenopausal women in the Diabetes Prevention Program.
By: Kim C, Barrett-Connor E, Randolph JF, Kong S, Nan B, Mather K, Golden SH and the Diabetes Prevention Program Research Group.

This study found that, among nonestrogen users, baseline sex steroids were not associated with reductions in weight or waistline circumference.

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Diagnosis and treatment of erectile dysfunction for reduction of cardiovascular risk.
By: Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, et al.
Erectile dysfunction is a marker of increased cardiovascular risk in younger men and in men with diabetes. Lifestyle improvements and treatment of dyslipidemia and hypertension are very important to lower cardiovascular risk.
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The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program.
By: Golden SH, Kim C, Barrett-Connor E, Nan B, Kong S, Goldberg R; the Diabetes Prevention Program Research Group.

It is unclear how lipids change in response to lifestyle modification or metformin among postmenopausal glucose intolerant women using and not using hormone therapy (HT). We examined the one-year changes in lipids among postmenopausal, prediabetic women in the Diabetes Prevention Program (DPP), and whether changes were mediated by sex hormones. The beneficial effects of ILS and metformin on lowering LDL-C and raising HDL-C differ depending upon concurrent HT use.

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Nonalcoholic fatty liver disease and serum lipoproteins: the Multi-Ethnic Study of Atherosclerosis.
By: DeFilippis AP, Blaha MJ, Martin SS, Reed RM, Jones SR, Nasir K, Blumenthal RS, Budoff MJ.
This study found that, after adjustment for multiple metabolic risk factors, adiposity, and measures of insulin resistance, there may be a link between nonalcoholic fatty liver disease and dyslipidemia.
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Impact of fitness versus obesity on routinely measured cardiometabolic risk in young, healthy adults.
By: Vranian MN, Keenan T, Blaha MJ, Silverman MG, Michos ED, Minder CM, Blumenthal RS, Nasir K, Meneghelo RS, Santos RD.
Although fitness and obesity are independently associated with cardiometabolic risk, and their effects are additive, obesity is more strongly associated with this risk when fitness and obesity are discordant. These findings underscore the need for weight loss in obese patients and suggest an unmeasured benefit of fitness.
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