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Ciccarone Center Research
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- Antiplatelet Therapy
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- Meet the Authors
Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the Multi-Ethnic Study of Atherosclerosis: A secondary analysis of a prospective, population-based cohort.
The potent predictive value of coronary artery calcium burden applies to middle-aged as well as older adults.Published in: Mayo Clinic ProceedingsRead on Pubmed
This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.Published in: American Journal of CardiologyRead on Pubmed
Coronary artery plaque, especially noncalcified plaque, is more prevalent and extensive in HIV-infected men, independent of CAD risk factors.Published in: Annals of Internal MedicineRead on Pubmed
Is there a role for coronary artery calcium scoring for management of asymptomatic patients at risk for coronary artery disease?: Clinical risk scores are not sufficient to define primary prevention treatment strategies among asymptomatic patients.Read on Pubmed
Subclinical atherosclerosis testing with CAC is currently superior to any combination of risk factors and serum biomarkers.
Critical review of high-sensitivity C-reactive protein and coronary artery calcium for the guidance of statin allocation: head-to-head comparison of the JUPITER and St. Francis Heart Trials.Read on Pubmed
This analysis looks at the strengths and limitations of two large trials of statin therapy based on persons with an elevated hsCRP, CAC score, or both.
Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis.Read on Pubmed
CAC scoring can help match statin therapy to absolute atherosclerotic CVD risk.
Associations of Pentraxin 3 with cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis.
In a study of apparently healthy adults, Pentraxin 3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independent of C-reactive protein (CRP) and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP and may provide additional insight into the development and progression of atherosclerosis.
Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: the MASALA and MESA studies.
A high burden of subclinical coronary atherosclerosis in South Asians may partly explain higher rates of cardiovascular disease in South Asians.
Epicardial fat is associated with duration of antiretroviral therapy and coronary atherosclerosis.
Greater epicardial fat volume in HIV-infected men and its association with coronary plaque and antiretroviral therapy duration suggest potential mechanisms that might lead to increased risk for cardiovascular disease in HIV.
Usefulness of coronary and carotid imaging rather than traditional atherosclerotic risk factors to identify firefighters at increased risk for cardiovascular disease.
Early detection and integration of imaging with traditional risk assessment will be important in preventing premature death and disability among firefighters.
Screening low-risk individuals for coronary artery disease.
Data regarding the role of additional testing in low-risk populations to improve early detection or to enhance risk assessment indicate that CAC and the ankle-brachial index (ABI) may be helpful for improving risk classification and detecting the higher-risk people from among those at lower risk.
Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis.
African-Americans have a lower prevalence, and Hispanics have a higher prevalence, of fatty liver than do other ethnicities. There are distinct ethnic variations in the prevalence of fatty liver even in patients with the metabolic syndrome or obesity, suggesting that genetic factors may play a substantial role in the phenotypic expression of fatty liver.
Ten-year trends in coronary calcification in individuals without clinical cardiovascular disease in the multi-ethnic study of atherosclerosis.
Researchers reported a significant secular trend toward increased prevalence of CAC over 10 years among African-Americans and no change in three other ethnic groups..
Risk and the physics of clinical prediction.
This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.
Associations between HIV infection and subclinical coronary atherosclerosis.
Coronary artery plaque, especially noncalcified plaque, is more prevalent and extensive in HIV-infected men, independent of CAD risk factors.