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School of Medicine
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Sherita Golden, MD, MHS
Ciccarone Center Research
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- Meet the Authors
Health disparities in endocrine disorders: Biological, clinical, and nonclinical factors — an Endocrine Society Scientific Statement.There is little evidence that genetic differences contribute significantly to race/ethnic disparities in the endocrine disorders examined. Multilevel interventions have reduced disparities in diabetes care, and these successes can be modeled to design similar interventions for other endocrine diseases.Read on Pubmed
A systematic review and meta-analysis of the association between depression and insulin resistance.
This study found that a small but significant cross-sectional association was observed between depression and insulin resistance, despite heterogeneity between studies.
Metabolic syndrome risk profiles among African-American adolescents: national health and nutrition examination survey, 2003-2010.
Although African American adolescents have the highest prevalence of obesity, they have the lowest prevalence of metabolic syndrome across all definitions used in previous research. To address this paradox, we sought to develop a model of the metabolic syndrome specific to African American adolescents. Our findings provide a plausible model of the metabolic syndrome specific to African American adolescents. Based on this model, approximately 19 and 16% of African American boys and girls, respectively, are at high risk for having the metabolic syndrome.
Diurnal salivary is associated with body mass index and waist circumference: the multi-ethnic study of atherosclerosis.
Neuroendocrine abnormalities, such as activation of the hypothalamic-pituitary-adrenal (HPA) axis, are associated with obesity; however, few large-scale population-based studies have examined HPA axis and markers of obesity. We examined the cross-sectional association of the cortisol awakening response (CAR) and diurnal salivary cortisol curve with obesity. Higher BMI and WC are associated with neuroendocrine dysregulation, which is present in a large population sample, and only partially explained by other covariates
Diurnal salivary cortisol is associated with body mass index and waist circumference: the multiethnic study of atherosclerosis.
Researchers showed that higher body mass index and waistline circumference are associated with neuroendocrine dysregulation, which is present in a large population sample, and only partially explained by other covariates.
Long-term effects of the Diabetes Prevention Program interventions on cardiovascular risk factors: a report from the DPP Outcomes Study.
This study investigated the long-term differences in cardiovascular disease risk factors and the use of lipid and blood pressure medications by the original Diabetes Prevention Program intervention group.
Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program.
Reductions in glucose among postmenopausal women who use and do not use estrogen therapy.
Among postmenopausal women who do not use estrogen therapy (ET), we have previously reported that intensive lifestyle modification (ILS) leads to increases in sex hormone-binding globulin (SHBG) and that such increases are associated with reductions in fasting plasma glucose (FPG) and 2-hour postchallenge glucose (2HG). Oral ET decreases FPG and increases 2HG while increasing both SHBG and estradiol (E2). It is unknown if ILS reduces glucose among ET users, if changes in SHBG and E2 might mediate any glucose decreases in ET users, and if these patterns differ from those in non-ET users. We conclude that among glucose-intolerant ET users, interventions to reduce glucose are effective but possibly mediated through different pathways than among women who do not use ET.
Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program.
Among postmenopausal glucose-intolerant women not using estrogen, intensive lifestyle modification increased SHBG levels and lower DHEA levels. These changes are associated with lower glucose independent of adiposity and insulin. Metformin effects upon endogenous sex hormones are not significant.
Diurnal salivary cortisol and urinary catecholamines are associated with diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis.
Comparative effectiveness and safety of methods of insulin delivery and glucose monitoring for diabetes mellitus: A systematic review and meta-analysis.
Continuous subcutaneous insulin infusion and multiple daily injections have similar effects on glycemic control and hypoglycemia, except continuous subcutaneous insulin infusion has a favorable effect on glycemic control in adults with type 1 diabetes mellitus. For glycemic control, real-time continuous glucose monitoring is superior to self-monitoring of blood glucose, and sensor-augmented insulin pumps are superior to multiple daily injections and self-monitoring of blood glucose without increasing the risk for hypoglycemia.