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Ciccarone Center Research

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Vascular Imaging

Landmark Article

Association between lipoprotein associated phospholipase A2 mass and subclinical coronary and carotid atherosclerosis in retired national football league players.
By: Pokharel Y, Nambi V, Martin SS, Hoogeveen RC, Nasir K, Khera A, Wong ND, Jones PH, Boone J, Roberts AJ, Ballantyne CM, Virani SS.

Retired National Football League (NFL) players were reported to have high prevalence of cardiovascular risk factors. Lipoprotein Associated Phospholipase A2 (LpPLA2) has shown to be associated with cardiovascular disease in the general population, but it is unknown whether such an association exists in retired NFL players. Our objective was to assess whether LpPLA2 mass was associated with coronary artery calcium (CAC) and carotid artery plaque (CAP) in retired NFL players. LpPLA2 mass was not associated with coronary or carotid subclinical atherosclerosis in retired NFL players.

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Neck circumference is not associated with subclinical atherosclerosis in retired national football league players.
By: Pokharel Y, Macedo FY, Nambi V, Martin SS, Nasir K, Wong ND, Boone J, Roberts AJ, Ballantyne CM, Virani SS.
In retired NFL players with a high prevalence of CAC and carotid artery plaque, neck circumference was not associated with coronary or carotid subclinical atherosclerosis.
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Vitamin D and subclinical cerebrovascular disease: The Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study.
By: Michos ED, Carson KA, Schneider AL, Lutsey PL, Xing L, Sharrett AR, Alonso A, Coker LH, Gross M, Post W, Mosley TH, Gottesman RF.
single measure of 25-hydroxy vitamin D was not cross-sectionally associated with white matter hyper-intensities grade or prevalent subclinical infarcts and was not prospectively associated with their progression or subclinical brain infarcts seen on serial cerebral MRIs obtained approximately 10 years apart.
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Associations of common carotid intima-media thickness with coronary heart disease risk factors and events vary with distance from the carotid bulb.
By: Polak JF, Post WS, Carr JJ, Szklo M, O’Leary DH.
Common carotid artery intima-media thickness (IMT) measurements made below the carotid bulb are smaller but have more consistent associations with CHD risk factors and outcomes compared with IMT measured near the bulb.
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Two classic hemodynamic findings for hypertrophic cardiomyopathy.
By: Barth AS, Abraham T, Ndumele C, Zakaria S.
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Vulnerability of the developing heart to oxygen deprivation as a cause of congenital heart defects.
By: Kenchegowda D, Liu H, Thompson K, Luo L, Martin SS, Fisher SA.
Low oxygen concentrations and lack of oxygen reserve during a critical phase of heart organogenesis may provide a basis for vulnerability to the development of common septation and conotruncal heart defects.
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Comparison of the relation between left ventricular anatomy and QRS duration in patients with cardiomyopathy with versus without left bundle branch block.
By: Chan DD, Wu KC, Loring Z, Galeotti L, Gerstenblith G, Tomaselli G, Weiss RG, Wagner GS, Strauss DG.
Increasing left ventricular (LV) anatomical measurements were associated with increasing QRS duration in patients with cardiomyopathy.
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Incident stroke is associated with common carotid artery diameter and not common carotid artery intima-media thickness.
By: Polak JF, Sacco RL, Post WS, Vaidya D, Arnan MK, O’Leary DH.
Though common carotid IMT is not associated with stroke, inter-adventitial diameter of the common carotid artery is independently associated with first-time incident ischemic stroke even after adjusting for IMT.
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Usefulness of coronary and carotid imaging rather than traditional atherosclerotic risk factors to identify firefighters at increased risk for cardiovascular disease.
By: Ratchford EV, Carson KA, Jones SR, Ashen MD.
Early detection and integration of imaging with traditional risk assessment will be important in preventing premature death and disability among firefighters.
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Screening low-risk individuals for coronary artery disease.
By: Desai CS, Blumenthal RS, Greenland P.
Data regarding the role of additional testing in low-risk populations to improve early detection or to enhance risk assessment indicate that CAC and the ankle-brachial index (ABI) may be helpful for improving risk classification and detecting the higher-risk people from among those at lower risk.
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