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Ciccarone Articles

Ciccarone Center Research


Cardiovascular Risk Assessment

Landmark Articles

The prevention of cardiovascular disease among women.
By: Michos ED.
The prognostic value of exercise capacity in patients with coronary artery disease: The FIT Project.
By: Hung RK, Al-Mallah MH, McEvoy JW, Whelton SP, Blumenthal RS, Nasir K, Schairer JR, Brawner C, Alam M, Keteyian SJ, Blaha MJ.
Exercise capacity was a strong predictor of morbidity and mortality in patients with coronary artery disease. Patients with similar exercise capacities had equivalent mortality risk, irrespective of baseline revascularization status.
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Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the Multi-Ethnic Study of Atherosclerosis: A secondary analysis of a prospective, population-based cohort.
By: Tota-Maharaj R, Blaha MJ, Blankstein R, Silverman M, Eng J, Shaw LJ, Blumenthal RS, Budoff MJ, Nasir K.
The potent predictive value of coronary artery calcium burden applies to middle-aged as well as older adults.
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Association between lipoprotein associated phospholipase A2 mass and subclinical coronary and carotid atherosclerosis in retired national football league players.
By: Pokharel Y, Nambi V, Martin SS, Hoogeveen RC, Nasir K, Khera A, Wong ND, Jones PH, Boone J, Roberts AJ, Ballantyne CM, Virani SS.

Retired National Football League (NFL) players were reported to have high prevalence of cardiovascular risk factors. Lipoprotein Associated Phospholipase A2 (LpPLA2) has shown to be associated with cardiovascular disease in the general population, but it is unknown whether such an association exists in retired NFL players. Our objective was to assess whether LpPLA2 mass was associated with coronary artery calcium (CAC) and carotid artery plaque (CAP) in retired NFL players. LpPLA2 mass was not associated with coronary or carotid subclinical atherosclerosis in retired NFL players.

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Novel biomarkers and risk factors.
By: Cheng HG, Martin SS, Jones SR.
Coronary artery calcium score.
By: Polonsky TS, Blumenthal RS, Greenland P.
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Rationale and design of the Henry Ford exercise testing project (The FIT Project).
By: Al-Mallah MH, Keteyian SJ, Brawner CA, Whelton S, Blaha MJ.
The FIT Project, the largest study of physical fitness to date, uses electronic clinical epidemiologic techniques to answer many clinically relevant questions related to exercise capacity and prognosis.
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New insights into diagnostic testing guidelines in women.
By: Metkus Jr. TS, Blumenthal RS, Joshi PH.

An update to the 2005 Guidelines on the Role of Noninvastive Testing in the Clinical Evaluation of Women with Suspected Ischemic Heart Disease was authored in response to the documented gap in appropriate diagnosis and treatment of ischemic heart disease between women and men.

Non-cardiovascular effects associated with statins.
By: Desai CS, Martin SS, Blumenthal RS.
This is a state-of-art review on the possible effects of statin therapy on organs not in the cardiovascular system.
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Is LDL-C measurement better than estimating absolute risk for treating increased cholesterol?
By: Feldman DI, Martin SS.

LDL-C measurements and absolute risk assessments are important and provide complimentary information. More research is needed, but based on the best available evidence it appears that a balance of estimating risk (ARR) and measuring LDL-C (RRR) is appropriate.