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Ciccarone Articles

Ciccarone Center Research


Heart Failure

Landmark Articles

Impaired left ventricular filling in COPD and emphysema: Is it the heart or the lungs?: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study.
By: Smith BM, Prince MR, Hoffman EA, Bluemke DA, Liu CY, Rabinowitz D, Hueper K, Parikh M, Gomes AS, Michos ED, Lima J, Barr RG.

These findings support a mechanism of upstream pulmonary causes of underfilling of the left ventricle in COPD and in patients with emphysema on computed tomography.

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Localization of myocardial scar in patients with cardiomyopathy and left bundle branch block using electrocardiographic Selvester QRS scoring.
By: Wieslander B, Wu KC, Loring Z, Andersson LG, Frank TF, Gerstenblith G, Tomaselli GF, Weiss RG, Wagner GS, Ugander M, Strauss DG.
This study describes the diagnostic performance of electrocardiographic criteria based on the Selvester QRS scoring system, first in localizing myocardial scar and second in screening for any non-septal scar in patients with strictly defined left bundle branch block.
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Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias.
By: DeMazumder D, Lake DE, Cheng A, Moss TJ, Guallar E, Weiss RG, Jones SR, Tomaselli GF, Moorman JR.

Implantable cardioverter-defibrillators (ICDs), the first line of therapy for preventing sudden cardiac death in high-risk patients, deliver appropriate shocks for termination of ventricular tachycardia (VT)/ventricular fibrillation. A common shortcoming of ICDs is imperfect rhythm discrimination, resulting in the delivery of inappropriate shocks for atrial fibrillation (AF). An underexplored area for rhythm discrimination is the difference in dynamic properties between AF and VT/ventricular fibrillation. We hypothesized that the higher entropy of rapid cardiac rhythms preceding ICD shocks distinguishes AF from VT/ventricular fibrillation. This new strategy for AF discrimination based on entropy estimation expands on simpler concepts of variability, performs well at fast heart rates, and has potential for broad clinical application.

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Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort.
By: Loring Z, Strauss DG, Gerstenblith G, Tomaselli GF, Weiss RG, Wu KC.
The findings from this study, which showed that the extent of myocardial scar is less in women than men, may have important implications for the future study of gender disparities in outcomes from implantable cardioverter-defibrillators and cardiac resynchronization therapy.
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Right, but not left, bundle branch block is associated with large anteroseptal scar.
By: Strauss DG, Loring Z, Selvester RH, Gerstenblith G, Tomaselli G, Weiss RG, Wagner GS, Wu KC.
This study concluded that right bundle branch block patients have significantly greater scar size than left bundle branch block patients.
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Pulmonary hyperinflation and left ventricular mass: the Multi-Ethnic Study of Atherosclerosis COPD Study.
By: Smith BM, Kawut SM, Bluemke DA, Basner RC, Gomes AS, Hoffman E, Kalhan R, Lima JA, Liu CY, Michos ED, Prince MR, Rabbani L, Rabinowitz D, Shimbo D, Shea S, Barr RG.
Pulmonary hyperinflation, as measured by residual lung volume or residual lung volume to total lung capacity ratio, is associated with greater left ventricular mass, an important predictor of heart failure and cardiovascular mortality.
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Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction.
By: Martin SS, Gosch K, Kulkarni KR, Spertus JA, Mathews R, Ho PM, Maddox TM, Newby LK, Alexander KP, Wang TY.
Findings from this study support targeted interventions in the transition of acute myocardial infarction care to promote affordable statin prescription at discharge, medication persistence and adherence, and cardiac rehabilitation participation.
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Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial.
By: Hare JM, Fishman JE, Gerstenblith G, et al.
This study showed that, in aggregate, an injection of mesenchymal stem cells as a therapy for patients with ischemic cardiomyopathy favorably affected their functional capacity, quality of life, and ventricular remodeling.
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Mitochondrial performance in heat acclimation—a lesson from ischemia/reperfusion and calcium overload insults in the heart.
By: Assayag M, Saada A, Gerstenblith G, Canaana H, Shlomai R, Horowitz M.


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Response to catecholamine stimulation of polymorphisms of the beta-1 and beta-2 adrenergic receptors.
By: McLean RC, Baird SW, Becker LC, Townsend SN, Gerstenblith G, Kass DA, Tomaselli GF, Schulman SP.
This study concludes that beta receptor gene variants significantly influence inotropic and chronotropic responses to beta-agonist exposure in patients on beta blocker therapy.
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