Obesity, subclinical myocardial injury and incident heart failure.
By: Ndumele CE, Coresh J, Lazo ML, Hoogeveen RC, Blumenthal RS, Folsom AR, Selvin E, Ballantyne CM, Nambi V.
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Headed in the right direction but at risk for miscalculation: a critical appraisal of the 2013 ACC/AHA risk assessment guideline.
By: Amin NP, Martin SS, Blaha MJ, Nasir K, Blumenthal RS, Michos ED.
The newly released 2013 ACC/AHA Guideline for Assessing Cardiovascular Risk was a major advance over prior guidelines, but the new risk equations do not appear to lead to significantly better discrimination than older models. Since the same risk factors are incorporated, using the new risk estimators may lead to inaccurate assessment of atherosclerotic cardiovascular risk in certain groups of patients. There also is likely an overestimation of risk when applied to modern populations. Future guidelines could provide clearer direction on which individuals would benefit from additional testing for more personalized preventive therapies.
- Journal:
Journal of the American College of Cardiology
- Year: 2014
- Topics:
Cholesterol / Lipids / Statins,
Cardiovascular Risk Assessment
- Read more articles by:
Roger S. Blumenthal, MD,
Michael Blaha, MD, MPH,
Erin Michos, MD, MHS,
Khurram Nasir, MD, MPH,
Seth Martin, MD, MHS
Read on Pubmed
2013 American cholesterol treatment guideline: what was done well and what could be done better.
By: Martin SS, Abd TT, Jones SR, Michos ED, Blumenthal RS, Blaha MJ.
This article critically appraises the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol. The guideline succeeds in prioritizing statin therapy, expanding focus to atherosclerotic cardiovascular disease including stroke, and in emphasizing absolute cardiovascular risk to determine statin eligibility.
- Journal:
Journal of the American College of Cardiology
- Year: 2014
- Topics:
ASCVD (Atherosclerotic Cardiovascular Disease),
Cholesterol / Lipids / Statins,
Cardiovascular Risk Assessment
- Read more articles by:
Roger S. Blumenthal, MD,
Michael Blaha, MD, MPH,
Erin Michos, MD, MHS,
Seth Martin, MD, MHS,
Steven Jones, MD
Read on Pubmed
Baseline subclinical atherosclerosis burden and distribution are associated with frequency and mode of future coronary revascularization: multi-ethnic study of atherosclerosis.
By: Silverman MG, Harkness JR, Blankstein R, Budoff MJ, Agatston AS, Carr JJ, Lima JA, Blumenthal RS, Nasir K, Blaha MJ.
There was a strong association between the baseline burden and regional distribution of CAC and the risk and type of future coronary revascularization among asymptomatic subjects.
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Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis).
By: Opdahl A, Ambale Venkatesh B, Fernandes VR, Wu CO, Nasir K, Choi EY, Almeida AL, Rosen B, Carvalho B, Edvardsen T, Bluemke DA, Lima JA.
Elevated resting heart rate was associated with increased risk for incident HF in asymptomatic participants in the MESA trial; higher heart rate was related to development of regional and global LV dysfunction independent of subclinical atherosclerosis and coronary heart disease.
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Polypill therapy, subclinical atherosclerosis, and cardiovascular events — implications for the use of preventive pharmacotherapy: MESA (Multi-Ethnic Study of Atherosclerosis).
By: Bittencourt MS, Blaha MJ, Blankstein R, Budoff M, Vargas JD, Blumenthal RS, Agatston AS, Nasir K.
The authors conclude that avoidance of polypill therapy in individuals with subclinical atherosclerosis could allow for a more selective use of the treatment and, as a result, avoidance of treatment in those who are unlikely to benefit.
- Journal:
Journal of the American College of Cardiology
- Year: 2014
- Topics:
ASCVD (Atherosclerotic Cardiovascular Disease),
Antiplatelet Therapy,
Blood Pressure,
Cholesterol / Lipids / Statins,
Quality of Care,
Cardiovascular Risk Assessment
- Read more articles by:
Roger S. Blumenthal, MD,
Michael Blaha, MD, MPH,
Khurram Nasir, MD, MPH
Read on Pubmed
Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).
By: Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E.
Intracoronary administration of autologous cardiosphere-derived cells did not raise significant safety concerns.
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How do statins work?: Changing paradigms with implications for statin allocation.
By: Blaha MJ, Martin SS.
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Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events.
By: Figueroa AL, Abdelbaky A, Truong QA, Corsini E, MacNabb MH, Lavender ZR, Lawler MA, Grinspoon SK, Brady TJ, Nasir K, Hoffmann U, Tawakol A.
Arterial fluorodeoxyglucose, measured from routinely obtained PET/CT images, substantially improved incident CVD prediction beyond Framingham risk score among individuals undergoing cancer surveillance.
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Non-high-density lipoprotein cholesterol, guideline targets, and population percentiles for secondary prevention in 1.3 million adults: the VLDL-2 study (very large database of lipids).
By: Elshazly MB, Martin SS, Blaha MJ, Joshi PH, Toth PP, McEvoy JW, Al-Hijji MA, Kulkarni KR, Kwiterovich PO, Blumenthal RS, Jones SR.
There is a significant patient-level discordance between non-HDL-C and LDL-C percentiles at lower LDL-C and higher triglyceride levels, which has implications for the treatment of high-risk patients.
- Journal:
Journal of the American College of Cardiology
- Year: 2013
- Topics:
Cholesterol / Lipids / Statins,
Cardiovascular Risk Assessment
- Read more articles by:
Roger S. Blumenthal, MD,
Michael Blaha, MD, MPH,
Seth Martin, MD, MHS,
J. Bill McEvoy, MB BCh, MHS,
Steven Jones, MD
Read on Pubmed
