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Ciccarone Center Research

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Hypertension

Response to importance of pressure pulse amplification in the association of resting heart rate and arterial stiffness.
By: Whelton SP, Blaha MJ.
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Association of resting heart rate with carotid and aortic arterial stiffness: Multi-Ethnic Study of Atherosclerosis.
By: Whelton SP, Blankstein R, Al-Mallah MH, Lima JA, Bluemke DA, Hundley WG, Polak JF, Blumenthal RS, Nasir K, Blaha MJ.

Results from this study suggest that a higher resting heart rate is associated with an increased arterial stiffness independent of atrioventricular nodal blocker use and physical activity level, with a stronger association for a peripheral (carotid) compared with a central (aorta) artery.

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Pharmacogenetics of antihypertensive response.
By: Campbell CY, Blumenthal RS.
We review the current status of the use of pharmacogenetic techniques to improve blood pressure control.
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Comparison of the Framingham Heart Study hypertension model with blood pressure alone in the prediction of risk of hypertension: the Multi-Ethnic Study of Atherosclerosis.
By: Muntner P, Woodward M, Mann DM, Shimbo D, Michos ED, Blumenthal RS, Carson AP, Chen H, Arnett DK.
In this multi-ethnic cohort of U.S. adults, the Framingham Heart Study model was not substantially better than systolic blood pressure (SBP) alone for predicting hypertension.
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Relationship of carotid distensibility and thoracic aorta calcification: multi-ethnic study of atherosclerosis.
By: Blaha MJ, Budoff M, Rivera JJ, Katz R, O’Leary DH, Polak JF, Takasu J, Blumenthal RS, Nasir K.
There is a strong independent association between carotid stiffness and thoracic aorta calcification. Carotid stiffness is more highly correlated with calcification of the aorta, a central elastic artery, than calcification of the coronary arteries. The prognostic significance of these findings requires longitudinal follow-up of the MESA cohort.
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