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Atherosclerosis

Association between lipoprotein associated phospholipase A2 mass and subclinical coronary and carotid atherosclerosis in retired national football league players.
By: Pokharel Y, Nambi V, Martin SS, Hoogeveen RC, Nasir K, Khera A, Wong ND, Jones PH, Boone J, Roberts AJ, Ballantyne CM, Virani SS.

Retired National Football League (NFL) players were reported to have high prevalence of cardiovascular risk factors. Lipoprotein Associated Phospholipase A2 (LpPLA2) has shown to be associated with cardiovascular disease in the general population, but it is unknown whether such an association exists in retired NFL players. Our objective was to assess whether LpPLA2 mass was associated with coronary artery calcium (CAC) and carotid artery plaque (CAP) in retired NFL players. LpPLA2 mass was not associated with coronary or carotid subclinical atherosclerosis in retired NFL players.

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Coronary computed tomography as a cost-effective test strategy for coronary artery disease assessment — a systematic review.
By: Zeb I, Abbas N, Nasir K, Budoff MJ.
CCTA may represent a cost-effective strategy and may be associated with less downstream testing for diagnosis of stable chest pain patients in low- to intermediate-risk patients; for low-risk acute chest pain patients; however, use of CCTA is associated with expedited patient management, less cost and safe exclusion of acute coronary syndrome.
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Coronary artery calcium and physical fitness — the two best predictors of long-term survival.
By: Blaha MJ, Feldman DI, Nasir K.
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Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: the MASALA and MESA studies.
By: Kanaya AM, Kandula NR, Ewing SK, Herrington D, Liu K, Blaha MJ, Srivastava S, Dave SS, Budoff MJ.
A high burden of subclinical coronary atherosclerosis in South Asians may partly explain higher rates of cardiovascular disease in South Asians.
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ABI and stroke: action at a distance and a call to action.
By: McEvoy JW, Nasir K.
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Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA).
By: Linefsky JP, O’Brien KD, Sachs M, Katz R, Eng J, Michos ED, Budoff MJ, de Boer I, Kestenbaum B.
Data indicate that serum phosphate levels are significantly associated with aortic valve calcification prevalence.
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Incremental prognostic value of coronary artery calcium score versus CT angiography among symptomatic patients without known coronary artery disease.
By: Hulten E, Bittencourt MS, Ghoshhajra B, O’Leary D, Christman MP, Blaha MJ, Truong Q, Nelson K, Montana P, Steigner M, Rybicki F, Hainer J, Brady TJ, Hoffmann U, Di Carli MF, Nasir K, Abbara S, Blankstein R.
Among symptomatic patients with a CAC score of zero, a very low (1-2%) prevalence of potentially obstructive CAD can occur, although this finding was not associated with future coronary revascularization or adverse prognosis within two years.
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Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA).
By: Pandey AK, Blaha MJ, Sharma K, Rivera J, Budoff MJ, Blankstein R, Al-Mallah M, Wong ND, Shaw L, Carr J, O’Leary D, Lima JA, Szklo M, Blumenthal RS, Nasir K.

A multiethnic, population-based study showed that a family history of premature CHD is associated with enhanced development and progression of subclinical disease, independent of other risk factors.

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Subclinical cardiovascular disease in plaque psoriasis: association or causal link?
By: Shaharyar S, Warraich H, McEvoy JW, Oni E, Ali SS, Karim A, Jamal O, Blaha MJ, Blumenthal RS, Fialkow J, Cury R, Budoff MJ, Agatston AA, Nasir K.

Since patients with psoriasis have an increased burden of subclinical atherosclerosis and endothelial dysfunction, those with greater severity and/or disease duration should be targeted for primary screening for cardiovascular disease risk reduction.

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Effect of statin treatment on coronary plaque progression — a serial coronary CT angiography study.
By: Zeb I, Li D, Nasir K, Malpeso J, Batool A, Flores F, Dailing C, Karlsberg RP, Budoff M.

Statin therapy resulted in significantly lower progression of low attenuation plaque and noncalcified plaques compared to nonstatin users.

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