In This Section      

Conditions We Treat: Hereditary Nonpolyposis Colorectal Cancer

Hereditary nonpolyposis colorectal cancer (HNPCC) syndrome was first described more than 100 years ago. It is the most common of the recognized inherited colorectal cancer syndromes.

Hereditary Nonpolyposis Colorectal Cancer (HNPCC): What You Need to Know

Woman on Laptop
  • HNPCC is an inherited condition, and the cancer may occur even if no polyps are present.
  • Symptoms of HNPCC cancer are often nonspecific and similar to other digestive disorders, so see your gastroenterologist for a definitive diagnosis.
  • Johns Hopkins Colon Cancer Risk Assessment Clinic evaluates patients who are at risk for developing colorectal cancer.
  • If your doctor found cancer, colorectal surgery offers you the best chance for a cure.

Also known as Lynch syndrome or cancer family syndrome, HNPCC is an inherited condition, meaning that the tendency to develop colorectal cancer is passed down in the family. “Nonpolyposis” means that the cancer can occur with only a small number of polyps present, or even with none at all.

Patient Resources

Request an Appointment


Why choose Johns Hopkins Division of Gastroenterology and Hepatology for hereditary nonpolyposis colorectal cancer?

GI physicians gathered around surgery table

Our Physicians

Backed by pioneering research, physicians at Johns Hopkins can offer innovative, effective care for people with or at risk of hereditary colorectal cancer.

Meet our physicians:

Our Services

The Colon Cancer Risk Assessment Clinic is specially designed to evaluate patients who have a family history of colon cancer.

Learn more about the clinic’s services.